The Potomac Highlands of West Virginia (or simply the Potomac Highlands) () centers on five West Virginian counties (Grant, Hampshire, Hardy, Mineral, and Pendleton) in the upper Potomac River watershed in the western portion of the state's Eastern Panhandle, bordering Maryland and Virginia. Because of geographical proximity, similar topography and landscapes, and shared culture and history, the Potomac Highlands region is also considered to include Pocahontas, Randolph, and Tucker counties, even though they are in the Monongahela River or New River watersheds and not the Potomac River watershed.[1]
The Potomac Highlands broadly overlap but are not identical with the four-state Allegheny Highlands or High Alleghenies region, which includes the relatively high and rugged mountains along and near the Allegheny Front from extreme southern Pennsylvania southward across Maryland and West Virginia into adjacent Virginia.