Pralidoxime

Pralidoxime
Clinical data
Other names1-methylpyridine-6-carbaldehyde oxime
AHFS/Drugs.comMicromedex Detailed Consumer Information
Pregnancy
category
  • C
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 2-[(hydroxyimino)methyl]-1-methylpyridin-1-ium
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.027.080 Edit this at Wikidata
Chemical and physical data
FormulaC7H9N2O+
Molar mass137.162 g·mol−1
3D model (JSmol)
  • ON=Cc1cccc[n+]1C
  • InChI=1S/C7H8N2O/c1-9-5-3-2-4-7(9)6-8-10/h2-6H,1H3/p+1 checkY
  • Key:JBKPUQTUERUYQE-UHFFFAOYSA-O checkY
  (verify)

Pralidoxime (2-pyridine aldoxime methyl chloride) or 2-PAM, usually as the chloride or iodide salts, belongs to a family of compounds called oximes that bind to organophosphate-inactivated acetylcholinesterase.[1] It is used to treat organophosphate poisoning[2] in conjunction with atropine and either diazepam or midazolam. It is a white solid.

  1. ^ Jokanović M, Stojiljković MP (December 2006). "Current understanding of the application of pyridinium oximes as cholinesterase reactivators in treatment of organophosphate poisoning". European Journal of Pharmacology. 553 (1–3): 10–7. doi:10.1016/j.ejphar.2006.09.054. PMID 17109842.
  2. ^ Jokanović M, Prostran M (2009). "Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds". Current Medicinal Chemistry. 16 (17): 2177–88. doi:10.2174/092986709788612729. PMID 19519385.