| PreQ1 riboswitch | |
|---|---|
 Predicted secondary structure and sequence conservation of PreQ1 | |
| Identifiers | |
| Symbol | PreQ1 |
| Rfam | RF00522 |
| Other data | |
| RNA type | Cis-reg; riboswitch |
| Domain(s) | Bacteria |
| SO | SO:0000035 |
| PDB structures | PDBe 2L1V |
The PreQ1-I riboswitch is a cis-acting element identified in bacteria which regulates expression of genes involved in biosynthesis of the nucleoside queuosine (Q) from GTP.[1] PreQ1 (pre-queuosine1) is an intermediate in the queuosine pathway, and preQ1 riboswitch, as a type of riboswitch, is an RNA element that binds preQ1. The preQ1 riboswitch is distinguished by its unusually small aptamer, compared to other riboswitches. Its atomic-resolution three-dimensional structure has been determined, with the PDB ID 2L1V.[2][3]
- ^ Roth A, Winkler WC, Regulski EE, Lee BW, Lim J, Jona I, Barrick JE, Ritwik A, Kim JN, Welz R, Iwata-Reuyl D, Breaker RR (2007). "A riboswitch selective for the queuosine precursor preQ1 contains an unusually small aptamer domain". Nat Struct Mol Biol. 14 (4): 308–317. doi:10.1038/nsmb1224. PMID 17384645. S2CID 32367656.
- ^ Klein DJ, Edwards TE, Ferré-D'Amaré AR (March 2009). "Cocrystal structure of a class I preQ1 riboswitch reveals a pseudoknot recognizing an essential hypermodified nucleobase". Nat. Struct. Mol. Biol. 16 (3): 343–344. doi:10.1038/nsmb.1563. PMC 2657927. PMID 19234468.
- ^ Kang M, Peterson R, Feigon J (March 2009). "Structural Insights into riboswitch control of the biosynthesis of queuosine, a modified nucleotide found in the anticodon of tRNA". Mol. Cell. 33 (6): 784–790. doi:10.1016/j.molcel.2009.02.019. PMID 19285444.