| Prefibrotic primary myelofibrosis | |
|---|---|
| Other names | Pre-PMF, Early stage myelofibrosis |
| Specialty | Hematology and oncology |
Prefibrotic primary myelofibrosis (Pre-PMF) is a rare blood cancer, classified by the World Health Organization as a distinct type of myeloproliferative neoplasm in 2016.[1] The disease is progressive to overt primary myelofibrosis, though the rate of progression is variable and not all patients progress. Symptoms and presentation can mimic essential thrombocythemia, with the main differentiator for pre-PMF being the presence of fibrosis in the bone marrow.