Preprotachykinin

Preprotachykinins are precursor proteins that are modified into tachykinin peptides. Via alternative splicing and post-translational modifications, preprotachykinins produce multiple peptide neurotransmitters.

There are two human preprotachykinins:[1]

  1. preprotachykinin-1 (also PPT-1, PPT-I, or PPT-A), which produces substance P and neurokinin A (also called "substance K"), and the derived neuropeptide K and neurokinin gamma.
  2. preprotachykinin-2 (also PPT-2, PPT-II, or PPT-B), which produces neurokinin B.
  1. ^ Helke CJ, Krause JE, Mantyh PW, Couture R, Bannon MJ (1 April 1990). "Diversity in mammalian tachykinin peptidergic neurons: multiple peptides, receptors, and regulatory mechanisms". FASEB Journal. 4 (6): 1606–15. doi:10.1096/fasebj.4.6.1969374. PMID 1969374. S2CID 25935155.