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| Prevotella-2 | |
|---|---|
 Consensus secondary structure and sequence conservation of Prevotella-2 RNA | |
| Identifiers | |
| Symbol | Prevotella-2 |
| Rfam | RF03043 |
| Other data | |
| RNA type | Gene; sRNA |
| SO | SO:0001263 |
| PDB structures | PDBe |
The Prevotella-2 RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] Energetically stable tetraloops often occur in this motif. Prevotella-2 motif RNAs are found in the bacterial genus Prevotella.
Nearly all Prevotella-2 RNAs occur upstream of genes that encode sodium/proton antiporters. These data suggest that the RNAs function as cis-regulatory elements. However, one Prevotella-2 RNA is located upstream of a gene encoded on the opposite DNA strand, which would be unlikely for a cis-regulatory function in bacteria. Therefore, it is also possible that Prevotella-2 RNAs are small RNAs that operate in trans. In this model, their association with sodium/proton antiporters would be a coincidence. Most Prevotella-2 RNAs are followed by a Rho-independent transcription terminator. If the RNAs function in cis, these transcript terminators might be a part of the mechanism used to achieve gene regulation. If, on the other hand, Prevotella-2 RNAs correspond to small RNAs, the terminators may simply terminate the transcript containing this non-coding RNA.
- ^ Weinberg Z, Lünse CE, Corbino KA, Ames TD, Nelson JW, Roth A, Perkins KR, Sherlock ME, Breaker RR (October 2017). "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. doi:10.1093/nar/gkx699. PMC 5737381. PMID 28977401.