Resulting from inborn deficiencies in immune system
This article needs to be updated. Please help update this article to reflect recent events or newly available information.(March 2019)
Primary immunodeficiencies are disorders in which part of the body's immune system is missing or does not function normally.[1] To be considered a primaryimmunodeficiency (PID), the immune deficiency must be inborn, not caused by secondary factors such as other disease, drug treatment, or environmental exposure to toxins. Most primary immunodeficiencies are genetic disorders; the majority are diagnosed in children under the age of one, although milder forms may not be recognized until adulthood. While there are over 430 recognized inborn errors of immunity (IEIs) as of 2019, the vast majority of which are PIDs, most are very rare.[2][3][4] About 1 in 500 people in the United States are born with a primary immunodeficiency.[5] Immune deficiencies can result in persistent or recurring infections, auto-inflammatory disorders, tumors, and disorders of various organs. There are currently limited treatments available for these conditions; most are specific to a particular type of PID. Research is currently evaluating the use of stem cell transplants (HSCT) and experimental gene therapies as avenues for treatment in limited subsets of PIDs.