| Princess Marie Isabel Ana | |
|---|---|
 Portrait by Giuseppe Bonito, c.1748 | |
| Born | 30 April 1743 Museo di Capodimonte, Naples |
| Died | 5 March 1749 (aged 5) Museo di Capodimonte, Naples |
| Burial | 1749 |
| House | Bourbon |
| Father | Charles VII of Naples (later Charles III of Spain) |
| Mother | Maria Amalia of Saxony |
Princess Maria Isabel Ana of Naples and Sicily (30 April 1743 – 5 March 1749) was the third daughter of Charles VII of Naples and III of Sicily and his wife, Maria Amalia of Saxony, who later became King Charles III and Queen Maria Amalia of Spain. Princess Maria was the older sister of kings Charles IV of Spain and Ferdinand I of the Two Sicilies. She died before her father's accession to the Spanish throne, and thus never held the title of Infanta of Spain.