Profilin

Profilin
Profilin (blue) in complex with actin (green). (PDB code: 2BTF​)
Identifiers
Symbol	Profilin
Pfam	PF00235
InterPro	IPR002097
SMART	PROF
PROSITE	PS00414
SCOP2	2btf / SCOPe / SUPFAM
CDD	cd00148
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary PDB 2btf​

Profilin is an actin-binding protein involved in the dynamic turnover and reconstruction of the actin cytoskeleton.^[1] It is found in most eukaryotic organisms. Profilin is important for spatially and temporally controlled growth of actin microfilaments, which is an essential process in cellular locomotion and cell shape changes. This restructuring of the actin cytoskeleton is essential for processes such as organ development, wound healing, and the hunting down of infectious intruders by cells of the immune system.

Profilin also binds sequences rich in the amino acid proline in diverse proteins. While most profilin in the cell is bound to actin, profilins have over 50 different binding partners. Many of those are related to actin regulation, but profilin also seems to be involved in activities in the nucleus such as mRNA splicing.^[2]

Profilin is the major allergen (via IgE) present in birch, grass, and other pollen.^{[citation needed]}