Progestogen-only injectable contraceptive

Long-acting reversible contraceptives (LARC)
Long-acting reversible contraceptives (LARC)
Background
Type	Hormonal
First use	1957
Pregnancy rates (first year)
Perfect use	0.2%
Typical use	6%
Usage
Reversibility	Yes
User reminders	?
Advantages and disadvantages
STI protection	No

Progestogen-only injectable contraceptives (POICs) are a form of hormonal contraception and progestogen-only contraception that are administered by injection and providing long-lasting birth control.^[2]^[3] As opposed to combined injectable contraceptives, they contain only a progestogen without an estrogen, and include two progestin preparations:^[2]^[3]

Medroxyprogesterone acetate (brand names Depo-Provera, Provera, Depo-subQ Provera 104)^[4] – 150 mg (intramuscularly) or 104 mg (subcutaneously) every 3 months^[3]
Norethisterone enanthate (brand names NET EN, Noristerat, Norigest, Doryxas)^[5] – 200 mg (intramuscularly) every 2 months^[3]

^ Singh M, Saxena BB, Singh R, Kaplan J, Ledger WJ (1997). "Contraceptive efficacy of norethindrone encapsulated in injectable biodegradable poly-dl-lactide-co-glycolide microspheres (NET-90): phase III clinical study". Advances in Contraception. 13 (1): 1–11. doi:10.1023/a:1006519027168. PMID 9181181. S2CID 44918557. In 1957, Karl Junkmann developed norethindrone enanthate (NET-EN or Noristeroir), the first injectable contraceptive which was injected every two months [1].
^ ^a ^b P. F. A. van Look; Kristian Heggenhougen; Stella R. Quah (January 2011). Sexual and Reproductive Health: A Public Health Perspective. Academic Press. pp. 82–. ISBN 978-0-12-385009-6.
^ ^a ^b ^c ^d Nagrath Arun; Malhotra Narendra; Seth Shikha (15 December 2012). Progress in Obstetrics and Gynecology--3. Jaypee Brothers Medical Publishers Pvt. Ltd. pp. 416–. ISBN 978-93-5090-575-3.
^ Mary Lee; Archana Desai (2007). Gibaldi's Drug Delivery Systems in Pharmaceutical Care. ASHP. pp. 328–. ISBN 978-1-58528-136-7.
^ Chaudhuri (1 January 2007). Practice Of Fertility Control: A Comprehensive Manual (7Th ed.). Elsevier India. pp. 154–. ISBN 978-81-312-1150-2.