Progressive inflammatory neuropathy

Progressive inflammatory neuropathy
SpecialtyNeurology, immunology

Progressive inflammatory neuropathy is a autoimmune disease that was identified in a report, released on January 31, 2008, by the Centers for Disease Control and Prevention.[1] The first known outbreak of this neuropathy occurred in southeastern Minnesota in the United States. The disease was reported among slaughterhouse workers who appeared at various care facilities in the area reporting similar neurological symptoms.[2][3] The disease was later identified at slaughterhouses in Indiana and Nebraska as well.[4] The condition is characterized by acute paralysis, pain, fatigue, numbness, and weakness, especially in extremities.[5][6] It was initially believed that workers might have contracted the disease through inhaling aerosols from pig brains that were created by a machine at the slaughterhouse and that an autoimmune response to the particles might have produced their mysterious peripheral neuropathy.[1] These suspicions were confirmed in reports and investigations conducted at the Mayo Clinic in Rochester, Minnesota.[6][7][8][9]

  1. ^ a b "Investigation of Progressive Inflammatory Neuropathy Among Swine Slaughterhouse Workers---Minnesota, 2007---2008". Centers for Disease Control and Prevention. 2007-01-31. Retrieved 2008-02-04.
  2. ^ Brown, David. "Inhaling pig brains may be cause of new illness" (PDF). Retrieved 20 March 2012.
  3. ^ Genoways, Ted. "The Spam Factory's Dirty Secret". Retrieved 12 May 2012.
  4. ^ Holzbauer, Stacy. "Investigation into risk factors for progressive inflammatory neuropathy among swine abattoir workers in the united states" (PDF). Archived from the original (PDF) on 2 June 2013. Retrieved 1 May 2012.
  5. ^ DeAngelis, Tracy M.; Shen, Liang (1 October 2009). "Outbreak of Progressive Inflammatory Neuropathy Following Exposure to Aerosolized Porcine Neural Tissue". Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine. 76 (5): 442–447. doi:10.1002/msj.20132. PMID 19787653.
  6. ^ a b Rukovets, Olga. "Ani". mal model mirrors human form of occupational neuropathy in pork plant workers. Neurology Today. Archived from the original on 16 January 2013. Retrieved 19 March 2012.
  7. ^ Tracy, Jennifer A.; Dyck, P. James B. (1 June 2011). "Auto-immune polyradiculoneuropathy and a novel IgG biomarker in workers exposed to aerosolized porcine brain". Journal of the Peripheral Nervous System. 16: 34–37. doi:10.1111/j.1529-8027.2011.00303.x. PMID 21696495. S2CID 36231208.
  8. ^ Lachance, DH; Lennon, VA; Pittock, SJ; Tracy, JA; Krecke, KN; Amrami, KK; Poeschla, EM; Orenstein, R; Scheithauer, BW; Sejvar, JJ; Holzbauer, S; Devries, AS; Dyck, PJ (Jan 2010). "An outbreak of neurological autoimmunity with polyradiculoneuropathy in workers exposed to aerosolised porcine neural tissue: a descriptive study". Lancet Neurology. 9 (1): 55–66. doi:10.1016/S1474-4422(09)70296-0. PMID 19945916. S2CID 19696027.
  9. ^ Meeusen, Jeffrey W.; Klein, Christopher J.; Pirko, Istvan; Haselkorn, Keegan E.; Kryzer, Thomas J.; Pittock, Sean J.; Lachance, Daniel H.; Dyck, P. James; Lennon, Vanda A. (1 March 2012). "Potassium channel complex autoimmunity induced by inhaled brain tissue aerosol". Annals of Neurology. 71 (3): 417–426. doi:10.1002/ana.22674. PMC 3315155. PMID 22451206.