| Prolactin Receptor | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PRLR | ||||||
| NCBI gene | 5618 | ||||||
| HGNC | 9446 | ||||||
| OMIM | 176761 | ||||||
| PDB | 1RW5 | ||||||
| RefSeq | NM_000949 | ||||||
| UniProt | P16471 | ||||||
| Other data | |||||||
| Locus | Chr. 5 p13-p12 | ||||||
| |||||||
The prolactin receptor (PRLR) is a type I cytokine receptor[1] encoded in humans by the PRLR gene on chromosome 5p13-14. It is the receptor for prolactin (PRL). The PRLR can also bind to and be activated by growth hormone (GH) and human placental lactogen (hPL). The PRLR is expressed in the mammary glands, pituitary gland, and other tissues. It plays an important role in lobuloalveolar development of the mammary glands during pregnancy and in lactation.