Proliferating cell nuclear antigen

PCNA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4D2G, 1AXC, 1U76, 1U7B, 1UL1, 1VYJ, 1VYM, 1W60, 2ZVK, 2ZVL, 2ZVM, 3P87, 3TBL, 3VKX, 3WGW, 4RJF, 3JA9, 4ZTD, 5IY4, 5E0U, 5E0T, 5E0V
Identifiers
Aliases	PCNA, ATLD2, proliferating cell nuclear antigen
External IDs	OMIM: 176740; MGI: 97503; HomoloGene: 1945; GeneCards: PCNA; OMA:PCNA - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p12.3 Start 5,114,953 bp[1] End 5,126,626 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F2|2 64.15 cM Start 132,091,082 bp[2] End 132,095,234 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte ganglionic eminence ventricular zone trabecular bone gonad mucosa of sigmoid colon rectum mucosa of transverse colon appendix Top expressed in thymus tail of embryo ventricular zone genital tubercle epiblast yolk sac bone marrow embryo embryo zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function MutLalpha complex binding identical protein binding enzyme binding receptor tyrosine kinase binding DNA binding DNA polymerase binding damaged DNA binding dinucleotide insertion or deletion binding protein binding chromatin binding histone acetyltransferase binding estrogen receptor binding purine-specific mismatch base pair DNA N-glycosylase activity DNA polymerase processivity factor activity Cellular component nucleus replisome nucleoplasm extracellular exosome DNA replication factor C complex centrosome PCNA complex nuclear replication fork PCNA-p21 complex replication fork nuclear body chromatin Biological process replication fork processing translesion synthesis DNA replication nucleotide-excision repair, DNA gap filling protein sumoylation regulation of DNA replication transcription-coupled nucleotide-excision repair positive regulation of deoxyribonuclease activity nucleotide-excision repair, DNA incision error-free translesion synthesis positive regulation of DNA repair regulation of transcription involved in G1/S transition of mitotic cell cycle positive regulation of DNA replication response to lipid heart development DNA mismatch repair cellular response to DNA damage stimulus mitotic telomere maintenance via semi-conservative replication epithelial cell differentiation response to cadmium ion cell population proliferation telomere maintenance error-prone translesion synthesis cellular response to UV estrous cycle cellular response to hydrogen peroxide response to dexamethasone nucleotide-excision repair, DNA incision, 5'-to lesion liver regeneration response to estradiol response to oxidative stress DNA repair response to L-glutamate DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest DNA ligation leading strand elongation protein ubiquitination telomere maintenance via semi-conservative replication viral process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5111 18538 Ensembl ENSG00000132646 ENSMUSG00000027342 UniProt P12004 P17918 RefSeq (mRNA) NM_182649 NM_002592 NM_011045 RefSeq (protein) NP_002583 NP_872590 NP_035175 Location (UCSC) Chr 20: 5.11 – 5.13 Mb Chr 2: 132.09 – 132.1 Mb PubMed search [3] [4]
Wikidata
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Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer and achieves its processivity by encircling the DNA, where it acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin remodeling and epigenetics.^[5]

Many proteins interact with PCNA via the two known PCNA-interacting motifs PCNA-interacting peptide (PIP) box^[6] and AlkB homologue 2 PCNA interacting motif (APIM).^[7] Proteins binding to PCNA via the PIP-box are mainly involved in DNA replication whereas proteins binding to PCNA via APIM are mainly important in the context of genotoxic stress.^[8]