Proliferating cell nuclear antigen

PCNA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPCNA, ATLD2, proliferating cell nuclear antigen
External IDsOMIM: 176740; MGI: 97503; HomoloGene: 1945; GeneCards: PCNA; OMA:PCNA - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_182649
NM_002592

NM_011045

RefSeq (protein)

NP_002583
NP_872590

NP_035175

Location (UCSC)Chr 20: 5.11 – 5.13 MbChr 2: 132.09 – 132.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Cryo-EM structure of the DNA-bound PolD–PCNA processive complex

Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer and achieves its processivity by encircling the DNA, where it acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin remodeling and epigenetics.[5]

Many proteins interact with PCNA via the two known PCNA-interacting motifs PCNA-interacting peptide (PIP) box[6] and AlkB homologue 2 PCNA interacting motif (APIM).[7] Proteins binding to PCNA via the PIP-box are mainly involved in DNA replication whereas proteins binding to PCNA via APIM are mainly important in the context of genotoxic stress.[8]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132646Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027342Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Moldovan GL, Pfander B, Jentsch S (May 2007). "PCNA, the maestro of the replication fork". Cell. 129 (4): 665–679. doi:10.1016/j.cell.2007.05.003. PMID 17512402. S2CID 3547069.
  6. ^ Warbrick E (March 1998). "PCNA binding through a conserved motif". BioEssays. 20 (3): 195–199. doi:10.1002/(sici)1521-1878(199803)20:3<195::aid-bies2>3.0.co;2-r. PMID 9631646.
  7. ^ Gilljam KM, Feyzi E, Aas PA, Sousa MM, Müller R, Vågbø CB, et al. (September 2009). "Identification of a novel, widespread, and functionally important PCNA-binding motif". The Journal of Cell Biology. 186 (5): 645–654. doi:10.1083/jcb.200903138. PMC 2742182. PMID 19736315.
  8. ^ Mailand N, Gibbs-Seymour I, Bekker-Jensen S (May 2013). "Regulation of PCNA-protein interactions for genome stability". Nature Reviews. Molecular Cell Biology. 14 (5): 269–282. doi:10.1038/nrm3562. PMID 23594953. S2CID 25952152.