A prophage is a bacteriophage (often shortened to "phage") genome that is integrated into the circular bacterial chromosome or exists as an extrachromosomal plasmid within the bacterial cell.[1] Integration of prophages into the bacterial host is the characteristic step of the lysogenic cycle of temperate phages. Prophages remain latent in the genome through multiple cell divisions until activation by an external factor, such as UV light, leading to production of new phage particles that will lyse the cell and spread. As ubiquitous mobile genetic elements, prophages play important roles in bacterial genetics and evolution, such as in the acquisition of virulence factors.
- ^ Saussereau E, Debarbieux L (2012). "Bacteriophages in the Experimental Treatment of Pseudomonas aeruginosa Infections in Mice". Advances in Virus Research. Vol. 83. pp. 127–128. doi:10.1016/B978-0-12-394438-2.00004-9. ISBN 978-0-12-394438-2. PMID 22748810.