Propiomazine

Propiomazine
Clinical data
Trade namesPropavan, others
Other namesPropionylpromethazine; CB-1678; Wy-1359; NSC-169450
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration		Oral, IM, IV
ATC code
Legal status
Legal status
  • BR: Class C1 (Other controlled substances)[1]
  • In general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityOral: 33%[2]
Protein binding81%[3]
Elimination half-life9 hours[2]
Identifiers
  • 1-[10-(2-dimethylaminopropyl)-10H-phenothiazin-2-yl]propan-1-one
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.006.043 Edit this at Wikidata
Chemical and physical data
FormulaC20H24N2OS
Molar mass340.49 g·mol−1
3D model (JSmol)
  • O=C(c2cc1N(c3c(Sc1cc2)cccc3)CC(N(C)C)C)CC
  • InChI=1S/C20H24N2OS/c1-5-18(23)15-10-11-20-17(12-15)22(13-14(2)21(3)4)16-8-6-7-9-19(16)24-20/h6-12,14H,5,13H2,1-4H3 checkY
  • Key:UVOIBTBFPOZKGP-UHFFFAOYSA-N checkY
  (verify)

Propiomazine, sold under the brand name Propavan among others, is an antihistamine which is used to treat insomnia and to produce sedation and relieve anxiety before or during surgery or other procedures and in combination with analgesics as well as during labor.[4][additional citation(s) needed] Propiomazine is a phenothiazine,[4] but is not used therapeutically as a neuroleptic because it does not block dopamine receptors well.[citation needed]

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ a b Dehlin O, Bengtsson C, Rubin B (1997). "A comparison of zopiclone and propiomazine as hypnotics in outpatients: a multicentre, double-blind, randomized, parallel-group comparison of zopiclone and propiomazine in insomniacs". Curr Med Res Opin. 13 (10): 565–72. doi:10.1185/03007999709113330. PMID 9327191.
  3. ^ "Propiomazine".
  4. ^ a b Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 234–. ISBN 9789401144391. OCLC 1243535030.