Names | |
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Preferred IUPAC name
Propanoyl chloride | |
Other names
Propionic chloride; propionic acid chloride (1:1)
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Identifiers | |
3D model (JSmol)
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ECHA InfoCard | 100.001.064 |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C3H5ClO | |
Molar mass | 92.52 g·mol−1 |
Appearance | colorless liquid |
Density | 1.0646 g/cm3 |
Melting point | −94 °C (−137 °F; 179 K) |
Boiling point | 80 °C (176 °F; 353 K) |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards
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Corrosive, flammable; highly toxic |
Flash point | 54 °C (129 °F; 327 K) |
Lethal dose or concentration (LD, LC): | |
LD50 (median dose)
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100 mg/kg (rat, oral) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Propionyl chloride (also propanoyl chloride) is the organic compound with the formula CH3CH2C(O)Cl. It is the acyl chloride derivative of propionic acid. It undergoes the characteristic reactions of acyl chlorides.[1] It is a colorless, corrosive, volatile liquid.
It is used as a reagent for organic synthesis. In derived chiral amides and esters, the methylene protons are diastereotopic.[2]
There have been efforts[3] to schedule Propionyl chloride as a DEA List 1 Chemical as it can be used to synthesize fentanyl.