Propiram

Propiram
Clinical data
Routes of
administration		By mouth, injected
ATC code
  • none
Legal status
Legal status
Pharmacokinetic data
Bioavailability97%
Elimination half-life5.2 hours
Identifiers
  • N-(1-Methyl-2-piperidin-1-ylethyl)-N-pyridin-2-ylpropanamide
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.036.144 Edit this at Wikidata
Chemical and physical data
FormulaC16H25N3O
Molar mass275.396 g·mol−1
3D model (JSmol)
  • O=C(N(c1ncccc1)C(CN2CCCCC2)C)CC
  • InChI=1S/C16H25N3O/c1-3-16(20)19(15-9-5-6-10-17-15)14(2)13-18-11-7-4-8-12-18/h5-6,9-10,14H,3-4,7-8,11-13H2,1-2H3 checkY
  • Key:ZBAFFZBKCMWUHM-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Propiram (Algeril, Dirame, Bay 4503)[2] is a partial μ-opioid receptor agonist and weak μ antagonist analgesic from the ampromide family of drugs related to other drugs such as phenampromide and diampromide. It was invented in 1963 in the United Kingdom by Bayer[3] but was not widely marketed, although it saw some limited clinical use, especially in dentistry. Propiram reached Phase III clinical trials in the United States and Canada.[4]

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-03.
  2. ^ US3163654A Pyridine derivatives and their preparation (n-tertiary aminoalkyl-n-acyl)-amino pyridines
  3. ^ U.S. patent 3,163,654
  4. ^ Drug Facts & Comparisons (56th ed.). 2002.