Prostacyclin synthase

PTGIS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3B6H, 2IAG
Identifiers
Aliases	PTGIS, CYP8, CYP8A1, PGIS, PTGI, prostaglandin I2 (prostacyclin) synthase, prostaglandin I2 synthase
External IDs	OMIM: 601699; MGI: 1097156; HomoloGene: 37374; GeneCards: PTGIS; OMA:PTGIS - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	49,568,137 bp
RNA expression pattern
	Top expressed in
	parietal pleura; ; right coronary artery; ; saphenous vein; ; pericardium; ; left uterine tube; ; Descending thoracic aorta; ; ascending aorta; ; germinal epithelium; ; left coronary artery; ; vena cava;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	iron ion binding; isomerase activity; metal ion binding; monooxygenase activity; protein binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; prostaglandin-I synthase activity;
Cellular component	cytoplasm; integral component of membrane; endoplasmic reticulum membrane; membrane; caveola; nucleus; endoplasmic reticulum; extracellular space;
Biological process	prostaglandin metabolic process; positive regulation of execution phase of apoptosis; cellular response to interleukin-6; lipid metabolism; icosanoid metabolic process; cyclooxygenase pathway; fatty acid metabolic process; positive regulation of angiogenesis; fatty acid biosynthetic process; negative regulation of nitric oxide biosynthetic process; decidualization; cellular response to interleukin-1; positive regulation of peroxisome proliferator activated receptor signaling pathway; apoptotic signaling pathway; negative regulation of NF-kappaB transcription factor activity; negative regulation of inflammatory response; cellular response to hypoxia; embryo implantation; prostaglandin biosynthetic process; NAD biosynthesis via nicotinamide riboside salvage pathway;
	Sources:Amigo / QuickGO
Orthologs
	5740
	19223
	ENSG00000124212
	n/a
	Q16647
	O35074
	NM_000961
	NM_008968
	NP_000952
	NP_032994
	Wikidata
View/Edit Human	View/Edit Mouse

Search
PMC	articles
PubMed	articles
NCBI	proteins

prostaglandin-I synthase
prostaglandin-I synthase
	Cartoon diagram of human prostacyclin synthase. Heme group visible at center. From PDB: 2IAG
Identifiers
EC no.	5.3.99.4
CAS no.	65802-86-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

Prostaglandin-I synthase (EC 5.3.99.4) also known as prostaglandin I2 (prostacyclin) synthase (PTGIS) or CYP8A1 is an enzyme involved in prostanoid biosynthesis that in humans is encoded by the PTGIS gene.^[4] This enzyme belongs to the family of cytochrome P450 isomerases.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124212 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yokoyama C, Yabuki T, Inoue H, Tone Y, Hara S, Hatae T, Nagata M, Takahashi EI, Tanabe T (September 1996). "Human gene encoding prostacyclin synthase (PTGIS): genomic organization, chromosomal localization, and promoter activity". Genomics. 36 (2): 296–304. doi:10.1006/geno.1996.0465. PMID 8812456.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124212 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8812456-4] Yokoyama C, Yabuki T, Inoue H, Tone Y, Hara S, Hatae T, Nagata M, Takahashi EI, Tanabe T (September 1996). "Human gene encoding prostacyclin synthase (PTGIS): genomic organization, chromosomal localization, and promoter activity". Genomics. 36 (2): 296–304. doi:10.1006/geno.1996.0465. PMID 8812456.

[1]

[2]

[3]

[4]