Prostaglandin D2 synthase

PTGDS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4OS8, 2WWP, 3O19, 3O22, 3O2Y, 4IMN, 4IMO, 4ORR, 4ORS, 4ORU, 4ORW, 4ORX, 4ORY, 4OS0, 4OS3
Identifiers
Aliases	PTGDS, L-PGDS, LPGDS, PDS, PGD2, PGDS, PGDS2, prostaglandin D2 synthase
External IDs	OMIM: 176803; MGI: 99261; HomoloGene: 737; GeneCards: PTGDS; OMA:PTGDS - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	136,981,742 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	25,360,058 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; C1 segment; ; substantia nigra; ; putamen; ; apex of heart; ; right auricle; ; temporal lobe; ; amygdala; ; caudate nucleus;
	Top expressed in
	vestibular membrane of cochlear duct; ; olfactory tubercle; ; median eminence; ; arcuate nucleus; ; mammillary body; ; iris; ; optic nerve; ; pontine nuclei; ; retinal pigment epithelium; ; stria vascularis;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transporter activity; isomerase activity; fatty acid binding; prostaglandin-D synthase activity; protein binding; small molecule binding; retinoid binding;
Cellular component	cytoplasm; Golgi apparatus; rough endoplasmic reticulum; nuclear membrane; endoplasmic reticulum membrane; membrane; extracellular region; endoplasmic reticulum; perinuclear region of cytoplasm; extracellular exosome; nucleus; extracellular space;
Biological process	prostaglandin metabolic process; lipid metabolism; cyclooxygenase pathway; fatty acid metabolic process; fatty acid biosynthetic process; prostaglandin biosynthetic process; regulation of circadian sleep/wake cycle, sleep; transport;
	Sources:Amigo / QuickGO
Orthologs
	5730
	19215
	ENSG00000107317
	ENSMUSG00000015090
	P41222; Q5SQ11
	O09114
	NM_000954
	NM_008963
	NP_000945
	NP_032989
	Wikidata
View/Edit Human	View/Edit Mouse

Prostaglandin-H2 D-isomerase (PTGDS) is an enzyme that in humans is encoded by the PTGDS gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107317 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015090 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagata A, Suzuki Y, Igarashi M, Eguchi N, Toh H, Urade Y, Hayaishi O (May 1991). "Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins". Proceedings of the National Academy of Sciences of the United States of America. 88 (9): 4020–4. Bibcode:1991PNAS...88.4020N. doi:10.1073/pnas.88.9.4020. PMC 51585. PMID 1902577.
^ "Entrez Gene: PTGDS prostaglandin D2 synthase 21kDa (brain)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000107317 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015090 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1902577-5] Nagata A, Suzuki Y, Igarashi M, Eguchi N, Toh H, Urade Y, Hayaishi O (May 1991). "Human brain prostaglandin D synthase has been evolutionarily differentiated from lipophilic-ligand carrier proteins". Proceedings of the National Academy of Sciences of the United States of America. 88 (9): 4020–4. Bibcode:1991PNAS...88.4020N. doi:10.1073/pnas.88.9.4020. PMC 51585. PMID 1902577.

[entrez-6] "Entrez Gene: PTGDS prostaglandin D2 synthase 21kDa (brain)".

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