Prostaglandin DP2 receptor

PTGDR2
Identifiers
AliasesPTGDR2, CD294, CRTH2, DL1R, DP2, GPR44, prostaglandin D2 receptor 2
External IDsOMIM: 604837; MGI: 1330275; HomoloGene: 3508; GeneCards: PTGDR2; OMA:PTGDR2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004778

NM_009962

RefSeq (protein)

NP_004769

NP_034092

Location (UCSC)Chr 11: 60.85 – 60.86 MbChr 19: 10.91 – 10.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Prostaglandin D2 receptor 2 (DP2 or CRTH2) is a human protein encoded by the PTGDR2 gene and GPR44.[5] DP2 has also been designated as CD294 (cluster of differentiation 294). It is a member of the class of prostaglandin receptors which bind with and respond to various prostaglandins. DP2 along with prostaglandin DP1 receptor are receptors for prostglandin D2 (PGD2). Activation of DP2 by PGD2 or other cognate receptor ligands has been associated with certain physiological and pathological responses, particularly those associated with allergy and inflammation, in animal models and certain human diseases.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183134Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034117Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: GPR44 G protein-coupled receptor 44".