Prostaglandin DP2 receptor

PTGDR2
Identifiers
Aliases	PTGDR2, CD294, CRTH2, DL1R, DP2, GPR44, prostaglandin D2 receptor 2
External IDs	OMIM: 604837; MGI: 1330275; HomoloGene: 3508; GeneCards: PTGDR2; OMA:PTGDR2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.2 Start 60,850,933 bp[1] End 60,855,950 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 10,914,524 bp[2] End 10,919,875 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon apex of heart islet of Langerhans muscle of thigh granulocyte body of stomach monocyte left ventricle rectum putamen Top expressed in tracheobronchial tree blastocyst perirhinal cortex entorhinal cortex CA3 field embryo medulla oblongata primary motor cortex pons conceptus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function prostaglandin D receptor activity G protein-coupled receptor activity prostaglandin J receptor activity prostaglandin F receptor activity neuropeptide binding signal transducer activity peptide binding Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane neuron projection intracellular anatomical structure Biological process G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemotaxis positive regulation of G protein-coupled receptor signaling pathway immune response neuropeptide signaling pathway calcium-mediated signaling negative regulation of male germ cell proliferation signal transduction chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11251 14764 Ensembl ENSG00000183134 ENSMUSG00000034117 UniProt Q9Y5Y4 Q9Z2J6 RefSeq (mRNA) NM_004778 NM_009962 RefSeq (protein) NP_004769 NP_034092 Location (UCSC) Chr 11: 60.85 – 60.86 Mb Chr 19: 10.91 – 10.92 Mb PubMed search [3] [4]
Wikidata
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Prostaglandin D₂ receptor 2 (DP₂ or CRTH2) is a human protein encoded by the PTGDR2 gene and GPR44.^[5] DP₂ has also been designated as CD294 (cluster of differentiation 294). It is a member of the class of prostaglandin receptors which bind with and respond to various prostaglandins. DP₂ along with prostaglandin DP₁ receptor are receptors for prostglandin D₂ (PGD₂). Activation of DP₂ by PGD₂ or other cognate receptor ligands has been associated with certain physiological and pathological responses, particularly those associated with allergy and inflammation, in animal models and certain human diseases.