Prostaglandin EP4 receptor

PTGER4
Identifiers
AliasesPTGER4, EP4, EP4R, EP4 receptor, prostaglandin E receptor 4
External IDsOMIM: 601586; MGI: 104311; HomoloGene: 20261; GeneCards: PTGER4; OMA:PTGER4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000958

NM_001136079
NM_008965

RefSeq (protein)

NP_000949

NP_001129551
NP_032991

Location (UCSC)Chr 5: 40.68 – 40.69 MbChr 15: 5.24 – 5.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Prostaglandin E2 receptor 4 (EP4) is a prostaglandin receptor for prostaglandin E2 (PGE2) encoded by the PTGER4 gene in humans;[5] it is one of four identified EP receptors, the others being EP1, EP2, and EP3, all of which bind with and mediate cellular responses to PGE2 and also, but generally with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin receptors). EP4 has been implicated in various physiological and pathological responses in animal models and humans.[6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171522Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039942Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "PTGER3 prostaglandin e receptor 3 [Homo sapiens (Human)] - Gene - NCBI". Archived from the original on 2016-02-26. Retrieved 2017-01-24.
  6. ^ Woodward DF, Jones RL, Narumiya S (September 2011). "International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress". Pharmacological Reviews. 63 (3): 471–538. doi:10.1124/pr.110.003517. PMID 21752876.