Prostaglandin EP4 receptor

PTGER4
Identifiers
Aliases	PTGER4, EP4, EP4R, EP4 receptor, prostaglandin E receptor 4
External IDs	OMIM: 601586; MGI: 104311; HomoloGene: 20261; GeneCards: PTGER4; OMA:PTGER4 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	40,693,735 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	5,273,668 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; jejunal mucosa; ; glomerulus; ; mucosa of sigmoid colon; ; metanephric glomerulus; ; bronchial epithelial cell; ; visceral pleura; ; synovial joint; ; germinal epithelium; ; parietal pleura;
	Top expressed in
	renal corpuscle; ; hair follicle; ; conjunctival fornix; ; atrioventricular valve; ; blood; ; mesenteric lymph nodes; ; uterus; ; Paneth cell; ; left colon; ; ileum;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; prostaglandin receptor activity; signal transducer activity; protein binding; prostaglandin E receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; intracellular anatomical structure;
Biological process	negative regulation of integrin activation; positive regulation of inflammatory response; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; ERK1 and ERK2 cascade; response to mechanical stimulus; negative regulation of eosinophil extravasation; regulation of stress fiber assembly; JNK cascade; cellular response to mechanical stimulus; response to lipopolysaccharide; immune response; regulation of ossification; T-helper cell differentiation; bone development; negative regulation of inflammatory response; signal transduction; cellular response to prostaglandin E stimulus; G protein-coupled receptor signaling pathway; inflammatory response; adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Orthologs
	5734
	19219
	ENSG00000171522
	ENSMUSG00000039942
	P35408
	P32240
	NM_000958
	NM_001136079; NM_008965
	NP_000949
	NP_001129551; NP_032991
	Wikidata
View/Edit Human	View/Edit Mouse

Prostaglandin E₂ receptor 4 (EP₄) is a prostaglandin receptor for prostaglandin E2 (PGE₂) encoded by the PTGER4 gene in humans;^[5] it is one of four identified EP receptors, the others being EP₁, EP₂, and EP₃, all of which bind with and mediate cellular responses to PGE₂ and also, but generally with lesser affinity and responsiveness, certain other prostanoids (see Prostaglandin receptors). EP₄ has been implicated in various physiological and pathological responses in animal models and humans.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171522 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039942 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "PTGER3 prostaglandin e receptor 3 [Homo sapiens (Human)] - Gene - NCBI". Archived from the original on 2016-02-26. Retrieved 2017-01-24.
^ Woodward DF, Jones RL, Narumiya S (September 2011). "International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress". Pharmacological Reviews. 63 (3): 471–538. doi:10.1124/pr.110.003517. PMID 21752876.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171522 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039942 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[ncbi.nlm.nih.gov-5] "PTGER3 prostaglandin e receptor 3 [Homo sapiens (Human)] - Gene - NCBI". Archived from the original on 2016-02-26. Retrieved 2017-01-24.

[pmid21752876-6] Woodward DF, Jones RL, Narumiya S (September 2011). "International Union of Basic and Clinical Pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress". Pharmacological Reviews. 63 (3): 471–538. doi:10.1124/pr.110.003517. PMID 21752876.

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