Protease-activated receptor

coagulation factor II thrombin receptor
Identifiers
SymbolF2R
Alt. symbolsTR; HTR; CF2R; PAR1; PAR-1
NCBI gene2149
HGNC3537
OMIM187930
PDB3BEF
RefSeqNM_001992
UniProtP25116
Other data
LocusChr. 5 q13.3
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StructuresSwiss-model
DomainsInterPro
F2R like trypsin receptor 1
Identifiers
SymbolF2RL1
Alt. symbolsPAR2, GPR11
NCBI gene2150
HGNC3538
OMIM600933
PDB5NDD
RefSeqNM_005242
UniProtP55085
Other data
LocusChr. 5 q13.3
Search for
StructuresSwiss-model
DomainsInterPro
coagulation factor II thrombin receptor like 2
Identifiers
SymbolF2RL2
Alt. symbolsPAR3; PAR-3
NCBI gene2151
HGNC3539
OMIM601919
PDB2PUX
RefSeqNM_004101
UniProtO00254
Other data
LocusChr. 5 q13.3
Search for
StructuresSwiss-model
DomainsInterPro
F2R like thrombin or trypsin receptor 3
Identifiers
SymbolF2RL3
Alt. symbolsPAR4
NCBI gene9002
HGNC3540
OMIM602779
PDB2PV9
RefSeqNM_003950
UniProtQ96RI0
Other data
LocusChr. 19 p13.11
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StructuresSwiss-model
DomainsInterPro

Protease-activated receptors (PAR) are a subfamily of related G protein-coupled receptors that are activated by cleavage of part of their extracellular domain. They are highly expressed in platelets, and also on endothelial cells, fibroblasts, immune cells, myocytes, neurons, and tissues that line the gastrointestinal tract.[1]

Protease-activated receptors, or PARs, are not to be mistaken with PAR proteins, a group of regulators of cellular polarity[2] named after their associated partitioning phenotype.[3]

  1. ^ Macfarlane SR, Seatter MJ, Kanke T, Hunter GD, Plevin R (June 2001). "Proteinase-activated receptors" (abstract). Pharmacological Reviews. 53 (2): 245–282. PMID 11356985.
  2. ^ Munro EM (February 2006). "PAR proteins and the cytoskeleton: a marriage of equals". Current Opinion in Cell Biology. 18 (1): 86–94. doi:10.1016/j.ceb.2005.12.007. PMID 16364625.
  3. ^ Goldstein B, Macara IG (November 2007). "The PAR proteins: fundamental players in animal cell polarization". Developmental Cell. 13 (5): 609–622. doi:10.1016/j.devcel.2007.10.007. PMC 2964935. PMID 17981131.