Protein S

PROS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPROS1, PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6, protein S (alpha), protein S
External IDsOMIM: 176880; MGI: 1095733; HomoloGene: 264; GeneCards: PROS1; OMA:PROS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000313
NM_001314077

NM_011173

RefSeq (protein)

NP_000304
NP_001301006

NP_035303

Location (UCSC)Chr 3: 93.87 – 93.98 MbChr 16: 62.67 – 62.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein S (also known as PROS) is a vitamin K-dependent plasma glycoprotein synthesized in the liver. In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b-binding protein (C4BP). In humans, protein S is encoded by the PROS1 gene.[5][6] Protein S plays a role in coagulation.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184500Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022912Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lundwall A, Dackowski W, Cohen E, Shaffer M, Mahr A, Dahlbäck B, Stenflo J, Wydro R (September 1986). "Isolation and sequence of the cDNA for human protein S, a regulator of blood coagulation". Proc. Natl. Acad. Sci. U.S.A. 83 (18): 6716–20. Bibcode:1986PNAS...83.6716L. doi:10.1073/pnas.83.18.6716. PMC 386580. PMID 2944113.
  6. ^ Long GL, Marshall A, Gardner JC, Naylor SL (January 1988). "Genes for human vitamin K-dependent plasma proteins C and S are located on chromosomes 2 and 3, respectively". Somat. Cell Mol. Genet. 14 (1): 93–8. doi:10.1007/BF01535052. PMID 2829367. S2CID 31236887.