Protein Wnt-5a

WNT5A
Identifiers
Aliases	WNT5A, hWnt family member 5A
External IDs	OMIM: 164975; MGI: 98958; HomoloGene: 20720; GeneCards: WNT5A; OMA:WNT5A - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	55,490,539 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	28,249,405 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; parotid gland; ; decidua; ; oral cavity; ; germinal epithelium; ; gums; ; palpebral conjunctiva; ; gingival epithelium; ; urethra; ; periodontal fiber;
	Top expressed in
	tail of embryo; ; Gonadal ridge; ; molar; ; stria vascularis; ; vas deferens; ; hand; ; utricle; ; transitional epithelium of urinary bladder; ; genital tubercle; ; tooth germ;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein domain specific binding; DNA-binding transcription factor activity; chemoattractant activity involved in axon guidance; receptor tyrosine kinase-like orphan receptor binding; signaling receptor binding; cytokine activity; frizzled binding; receptor ligand activity; protein binding; phospholipid binding;
Cellular component	endocytic vesicle membrane; endoplasmic reticulum lumen; extracellular region; cell surface; extracellular exosome; plasma membrane; Golgi lumen; clathrin-coated endocytic vesicle membrane; extracellular space; clathrin-coated vesicle membrane; extracellular matrix; collagen-containing extracellular matrix; postsynapse; glutamatergic synapse;
Biological process	somitogenesis; cellular response to retinoic acid; planar cell polarity pathway involved in outflow tract morphogenesis; excitatory synapse assembly; non-canonical Wnt signaling pathway; positive regulation of protein phosphorylation; negative chemotaxis; positive regulation of protein catabolic process; paraxial mesoderm formation; convergent extension involved in axis elongation; positive regulation of protein kinase C activity; cellular response to molecule of bacterial origin; positive regulation of protein localization to synapse; hindgut morphogenesis; positive regulation of JNK cascade; mesodermal to mesenchymal transition involved in gastrulation; regulation of protein localization; heart looping; protein phosphorylation; epithelial cell proliferation involved in mammary gland duct elongation; face development; establishment of epithelial cell apical/basal polarity; notochord morphogenesis; positive regulation of mesenchymal cell proliferation; mesenchymal-epithelial cell signaling; negative regulation of epithelial cell proliferation; planar cell polarity pathway involved in cardiac muscle tissue morphogenesis; cellular response to interferon-gamma; positive regulation of thymocyte apoptotic process; tube closure; positive regulation of non-canonical Wnt signaling pathway; type B pancreatic cell development; negative regulation of mesenchymal cell proliferation; primitive streak formation; cellular response to transforming growth factor beta stimulus; cellular response to calcium ion; dopaminergic neuron differentiation; positive regulation of type I interferon-mediated signaling pathway; cell fate commitment; negative regulation of fat cell differentiation; limb morphogenesis; convergent extension; lung development; positive regulation of fibroblast proliferation; optic cup formation involved in camera-type eye development; hematopoietic stem cell proliferation; embryonic digit morphogenesis; regulation of branching involved in mammary gland duct morphogenesis; negative regulation of axon extension involved in axon guidance; positive regulation of peptidyl-serine phosphorylation; chemorepulsion of dopaminergic neuron axon; positive regulation of transcription, DNA-templated; negative regulation of prostatic bud formation; planar cell polarity pathway involved in cardiac right atrium morphogenesis; positive regulation of endocytosis; morphogenesis of an epithelium; JNK cascade; cartilage development; positive regulation of GTPase activity; axis elongation; embryonic limb morphogenesis; positive regulation of cartilage development; neural tube development; pericardium morphogenesis; positive regulation of interleukin-6 production; post-anal tail morphogenesis; convergent extension involved in organogenesis; digestive tract morphogenesis; roof of mouth development; cell differentiation; neuron projection morphogenesis; male gonad development; positive regulation of inflammatory response; lateral sprouting involved in mammary gland duct morphogenesis; positive regulation of macrophage cytokine production; positive regulation of epithelial cell proliferation; urinary bladder development; planar cell polarity pathway involved in ventricular septum morphogenesis; positive regulation of JUN kinase activity; establishment of planar polarity; hypophysis morphogenesis; negative regulation of synapse assembly; wound healing; positive regulation of macrophage activation; negative regulation of apoptotic process; positive regulation of ossification; planar cell polarity pathway involved in axis elongation; negative regulation of melanin biosynthetic process; positive regulation of angiogenesis; embryonic skeletal system development; cervix development; uterus development; Wnt signaling pathway, planar cell polarity pathway; Wnt signaling pathway, calcium modulating pathway; positive regulation of NF-kappaB transcription factor activity; epithelial to mesenchymal transition; canonical Wnt signaling pathway; planar cell polarity pathway involved in pericardium morphogenesis; positive regulation of protein binding; negative regulation of transcription, DNA-templated; ameboidal-type cell migration; midbrain development; planar cell polarity pathway involved in gastrula mediolateral intercalation; positive regulation of protein kinase activity; positive regulation of cell-cell adhesion mediated by cadherin; neurogenesis; activation of protein kinase B activity; positive regulation of endothelial cell proliferation; axonogenesis; non-canonical Wnt signaling pathway via JNK cascade; activation of GTPase activity; positive regulation of cytokine production; vagina development; positive regulation of protein kinase C signaling; development of primary male sexual characteristics; mammary gland branching involved in thelarche; positive regulation of interferon-gamma production; somite development; keratinocyte differentiation; planar cell polarity pathway involved in neural tube closure; axon guidance; negative regulation of BMP signaling pathway; positive regulation of endothelial cell migration; genitalia development; negative regulation of fibroblast growth factor receptor signaling pathway; positive regulation of response to cytokine stimulus; multicellular organism development; inhibitory synapse assembly; neural tube closure; determination of left/right symmetry; lens development in camera-type eye; positive regulation of peptidyl-threonine phosphorylation; cochlea morphogenesis; inner ear morphogenesis; positive regulation of T cell chemotaxis; olfactory bulb interneuron development; positive regulation of cell population proliferation; positive regulation of neuron projection development; positive regulation of meiotic nuclear division; melanocyte proliferation; cellular response to lipopolysaccharide; cell migration; anterior/posterior axis specification, embryo; chemoattraction of serotonergic neuron axon; positive regulation of transcription by RNA polymerase II; anterior/posterior pattern specification; midgut development; planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation; midbrain dopaminergic neuron differentiation; neuron differentiation; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; negative regulation of cell proliferation in midbrain; negative regulation of canonical Wnt signaling pathway; planar cell polarity pathway involved in axon guidance; Wnt signaling pathway; response to organic substance; positive regulation of timing of anagen; membrane organization; positive regulation of canonical Wnt signaling pathway; presynapse assembly; postsynapse assembly; regulation of signaling receptor activity; positive regulation of gene expression; regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of G protein-coupled receptor signaling pathway; regulation of inflammatory response; regulation of synapse organization; secondary palate development; regulation of postsynapse organization; regulation of postsynaptic cytosolic calcium ion concentration; positive regulation of neuron projection arborization; positive regulation of neuron death;
	Sources:Amigo / QuickGO
Orthologs
	7474
	22418
	ENSG00000114251
	ENSMUSG00000021994
	P41221
	P22725
	NM_001256105; NM_003392; NM_001377271; NM_001377272
	NM_001256224; NM_009524
	NP_001243034; NP_003383; NP_001364200; NP_001364201
	NP_001243153; NP_033550
	Wikidata
View/Edit Human	View/Edit Mouse

Protein Wnt-5a is a protein that in humans is encoded by the WNT5A gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114251 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021994 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Clark CC, Cohen I, Eichstetter I, Cannizzaro LA, McPherson JD, Wasmuth JJ, Iozzo RV (November 1993). "Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21". Genomics. 18 (2): 249–60. doi:10.1006/geno.1993.1463. PMID 8288227.
^ "Entrez Gene: WNT5A wingless-type MMTV integration site family, member 5A".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000114251 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021994 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8288227-5] Clark CC, Cohen I, Eichstetter I, Cannizzaro LA, McPherson JD, Wasmuth JJ, Iozzo RV (November 1993). "Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21". Genomics. 18 (2): 249–60. doi:10.1006/geno.1993.1463. PMID 8288227.

[entrez-6] "Entrez Gene: WNT5A wingless-type MMTV integration site family, member 5A".

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