Protein disulfide-isomerase

Protein disulfide-isomerase
Structural picture of human protein disulfide isomerase (PDB 1BJX)
Identifiers
Symbol?
InterProIPR005792
Protein disulfide-isomerase
Identifiers
EC no.5.3.4.1
CAS no.37318-49-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins
protein disulfide isomerase family A, member 2
Identifiers
SymbolPDIA2
Alt. symbolsPDIP
NCBI gene64714
HGNC14180
OMIM608012
RefSeqNM_006849
UniProtQ13087
Other data
LocusChr. 16 p13.3
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StructuresSwiss-model
DomainsInterPro
protein disulfide isomerase family A, member 3
Identifiers
SymbolPDIA3
Alt. symbolsGRP58
NCBI gene2923
HGNC4606
OMIM602046
RefSeqNM_005313
UniProtP30101
Other data
LocusChr. 15 q15
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StructuresSwiss-model
DomainsInterPro
protein disulfide isomerase family A, member 4
Identifiers
SymbolPDIA4
NCBI gene9601
HGNC30167
RefSeqNM_004911
UniProtP13667
Other data
LocusChr. 7 q35
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StructuresSwiss-model
DomainsInterPro
protein disulfide isomerase family A, member 5
Identifiers
SymbolPDIA5
NCBI gene10954
HGNC24811
RefSeqNM_006810
UniProtQ14554
Other data
EC number5.3.4.1
LocusChr. 3 q21.1
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StructuresSwiss-model
DomainsInterPro
protein disulfide isomerase family A, member 6
Identifiers
SymbolPDIA6
Alt. symbolsTXNDC7
NCBI gene10130
HGNC30168
RefSeqNM_005742
UniProtQ15084
Other data
LocusChr. 2 p25.1
Search for
StructuresSwiss-model
DomainsInterPro

Protein disulfide isomerase (EC 5.3.4.1), or PDI, is an enzyme in the endoplasmic reticulum (ER) in eukaryotes and the periplasm of bacteria that catalyzes the formation and breakage of disulfide bonds between cysteine residues within proteins as they fold.[1][2][3] This allows proteins to quickly find the correct arrangement of disulfide bonds in their fully folded state, and therefore the enzyme acts to catalyze protein folding.

  1. ^ Wilkinson B, Gilbert HF (June 2004). "Protein disulfide isomerase". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1699 (1–2): 35–44. doi:10.1016/j.bbapap.2004.02.017. PMID 15158710.
  2. ^ Gruber CW, Cemazar M, Heras B, Martin JL, Craik DJ (August 2006). "Protein disulfide isomerase: the structure of oxidative folding". Trends in Biochemical Sciences. 31 (8): 455–64. doi:10.1016/j.tibs.2006.06.001. PMID 16815710.
  3. ^ Galligan JJ, Petersen DR (July 2012). "The human protein disulfide isomerase gene family". Human Genomics. 6 (1): 6. doi:10.1186/1479-7364-6-6. PMC 3500226. PMID 23245351.