Protein kinase B

"AKT" redirects here. For other uses, see AKT (disambiguation).

AKT1
Ribbon Representation of crystal structure of Akt-1-inhibitor complexes.[1]
Identifiers
SymbolAKT1
NCBI gene207
HGNC391
OMIM164730
RefSeqNM_005163
UniProtP31749
Other data
LocusChr. 14 q32.32-32.33
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AKT2
Crystal structure of Akt-2-inhibitor complexes.[2]
Identifiers
SymbolAKT2
NCBI gene208
HGNC392
OMIM164731
RefSeqNM_001626
UniProtP31751
Other data
LocusChr. 19 q13.1-13.2
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AKT3
Identifiers
SymbolAKT3
NCBI gene10000
HGNC393
OMIM611223
RefSeqNM_181690
UniProtQ9Y243
Other data
LocusChr. 1 q43-44
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Protein kinase B (PKB), also known as Akt, is the collective name of a set of three serine/threonine-specific protein kinases that play key roles in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration.

  1. ^ PDB: 3MV5​; Freeman-Cook KD, Autry C, Borzillo G, Gordon D, Barbacci-Tobin E, Bernardo V, et al. (June 2010). "Design of selective, ATP-competitive inhibitors of Akt". Journal of Medicinal Chemistry. 53 (12): 4615–22. doi:10.1021/jm1003842. PMID 20481595.
  2. ^ PDB: 3D0E​; Heerding DA, Rhodes N, Leber JD, Clark TJ, Keenan RM, Lafrance LV, et al. (September 2008). "Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase". Journal of Medicinal Chemistry. 51 (18): 5663–79. doi:10.1021/jm8004527. PMID 18800763.