Protein phosphatase 1

"PP1" redirects here. For other uses, see Pp1.
PP1 plays an instrumental role in glycogen metabolism through its responsibility for the interconversion between phosphorylase a and b.

Protein phosphatase 1 (PP1) belongs to a certain class of phosphatases known as protein serine/threonine phosphatases. This type of phosphatase includes metal-dependent protein phosphatases (PPMs) and aspartate-based phosphatases. PP1 has been found to be important in the control of glycogen metabolism, muscle contraction, cell progression, neuronal activities, splicing of RNA, mitosis,[1] cell division, apoptosis, protein synthesis, and regulation of membrane receptors and channels.[2]

  1. ^ Tournebize R, Andersen SS, Verde F, Dorée M, Karsenti E, Hyman AA (September 1997). "Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosis". The EMBO Journal. 16 (18): 5537–49. doi:10.1093/emboj/16.18.5537. PMC 1170186. PMID 9312013.
  2. ^ Fong NM, Jensen TC, Shah AS, Parekh NN, Saltiel AR, Brady MJ (November 2000). "Identification of binding sites on protein targeting to glycogen for enzymes of glycogen metabolism". The Journal of Biological Chemistry. 275 (45): 35034–9. doi:10.1074/jbc.M005541200. PMID 10938087.