Protein wntless homolog

WLS
Identifiers
AliasesWLS, C1orf139, EVI, GPR177, MRP, mig-14, wntless Wnt ligand secretion mediator, Wnt ligand secretion mediator, ZKS
External IDsOMIM: 611514; MGI: 1915401; HomoloGene: 11779; GeneCards: WLS; OMA:WLS - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001002292
NM_001193334
NM_024911

NM_026582
NM_001356349
NM_001356350

RefSeq (protein)

NP_001002292
NP_001180263
NP_079187

NP_080858
NP_001343278
NP_001343279

Location (UCSC)Chr 1: 68.1 – 68.23 MbChr 3: 159.55 – 159.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein wntless homolog, commonly known as Wntless, is encoded in humans by the WLS gene .[5] Wntless is a receptor for Wnt proteins in Wnt-secreting cells.[6]

Wntless was shown to be a cargo for the retromer complex.[6] It has been found essential for hair follicle induction.[7]

A homozygous missense mutation in the WLS gene was identified in Zaki syndrome.[8]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116729Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028173Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "WLS - Protein wntless homolog - Homo sapiens (Human) - WLS gene & protein". www.uniprot.org. Retrieved 30 May 2022.
  6. ^ a b Eaton S (January 2008). "Retromer retrieves wntless". Developmental Cell. 14 (1): 4–6. doi:10.1016/j.devcel.2007.12.014. PMID 18194646.
  7. ^ Fu J, Hsu W (April 2013). "Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis". The Journal of Investigative Dermatology. 133 (4): 890–898. doi:10.1038/jid.2012.407. PMC 3594635. PMID 23190887.
  8. ^ Chai G, Szenker-Ravi E, Chung C, Li Z, Wang L, Khatoo M, et al. (September 2021). "A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion". The New England Journal of Medicine. 385 (14): 1292–1301. doi:10.1056/NEJMoa2033911. PMC 9017221. PMID 34587386.