Protoporphyrinogen oxidase

PPOX
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3NKS, 4IVM, 4IVO
Identifiers
Aliases	PPOX, PPO, V290M, VP, protoporphyrinogen oxidase
External IDs	OMIM: 600923; MGI: 104968; HomoloGene: 262; GeneCards: PPOX; OMA:PPOX - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 161,166,056 bp[1] End 161,178,013 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H3 Start 171,103,563 bp[2] End 171,108,760 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube olfactory zone of nasal mucosa epithelium of bronchus right hemisphere of cerebellum bronchial epithelial cell left ovary anterior pituitary right ovary granulocyte canal of the cervix Top expressed in fetal liver hematopoietic progenitor cell granulocyte neural layer of retina tibiofemoral joint human fetus right kidney saccule yolk sac genital tubercle neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function flavin adenine dinucleotide binding oxidoreductase activity oxygen-dependent protoporphyrinogen oxidase activity Cellular component mitochondrial inner membrane mitochondrial intermembrane space intrinsic component of mitochondrial inner membrane membrane mitochondrion integral component of mitochondrial inner membrane mitochondrial membranes Biological process heme biosynthetic process protoporphyrinogen IX metabolic process protoporphyrinogen IX biosynthetic process porphyrin-containing compound biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5498 19044 Ensembl ENSG00000143224 ENSMUSG00000062729 UniProt P50336 P51175 RefSeq (mRNA) NM_000309 NM_001122764 NM_001350128 NM_001350129 NM_001350130 NM_001350131 NM_001365398 NM_001365399 NM_001365400 NM_001365401 NM_008911 RefSeq (protein) NP_000300 NP_001116236 NP_001337057 NP_001337058 NP_001337059 NP_001337060 NP_032937 Location (UCSC) Chr 1: 161.17 – 161.18 Mb Chr 1: 171.1 – 171.11 Mb PubMed search [3] [4]
Wikidata
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protoporphyrinogen oxidase
Heme synthesis—note that some reactions occur in the cytoplasm and some in the mitochondrion (yellow)
Identifiers
EC no.	1.3.3.4
CAS no.	53986-32-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Protoporphyrinogen oxidase or protox is an enzyme that in humans is encoded by the PPOX gene.^[5][6][7]

Protoporphyrinogen oxidase is responsible for the seventh step in biosynthesis of protoporphyrin IX. This porphyrin is the precursor to hemoglobin, the oxygen carrier in animals, and chlorophyll, the dye in plants. The enzyme catalyzes the dehydrogenation (removal of hydrogen atoms) of protoporphyrinogen IX (the product of the sixth step in the production of heme) to form protoporphyrin IX. One additional enzyme must modify protoporphyrin IX before it becomes heme. Inhibition of this enzyme is a strategy used in certain herbicides.