Pulmonary venoocclusive disease

Pulmonary veno-occlusive disease
Other namesObstructive disease of the pulmonary veins[1]
Pulmonary veno-occlusive disease-Intimal fibrosis with marked narrowing of lumen of a large pulmonary vein
SpecialtyPulmonology, cardiology Edit this on Wikidata
SymptomsShortness of breath, fatigue[2]
CausesNarrow pulmonary vein, Pulmonary artery hypertension[2]
Diagnostic methodChest x-ray, Chest CT[2]
TreatmentVasodilators can be used[2]

Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension caused by progressive blockage of the small veins in the lungs.[2] The blockage leads to high blood pressures in the arteries of the lungs, which, in turn, leads to heart failure. The disease is progressive and fatal, with median survival of about 2 years from the time of diagnosis to death.[3] The definitive therapy is lung transplantation.[4]

  1. ^ "Pulmonary venoocclusive disease | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". rarediseases.info.nih.gov. Retrieved 31 July 2019.
  2. ^ a b c d e Cite error: The named reference NIH was invoked but never defined (see the help page).
  3. ^ Escribano (2012). "Survival in pulmonary hypertension in Spain: insights from the Spanish registry". Eur Respir J. 40 (3): 596–603. doi:10.1183/09031936.00101211. PMID 22362843.
  4. ^ Ye (2011). "Lengthy Diagnostic Challenge in a Rare Case of Pulmonary Veno-Occlusive Disease: Case Report and Review of the Literature". Intern Med. 50 (12): 1323–7. doi:10.2169/internalmedicine.50.5035. PMID 21673470.