| Purine riboswitch | |
|---|---|
 Predicted secondary structure and sequence conservation of Purine | |
| Identifiers | |
| Symbol | Purine |
| Rfam | RF00167 |
| Other data | |
| RNA type | Cis-reg; riboswitch |
| Domain(s) | Bacteria |
| SO | SO:0000035 |
| PDB structures | PDBe |
A purine riboswitch is a sequence of ribonucleotides in certain messenger RNA (mRNA) that selectively binds to purine ligands via a natural aptamer domain.[1] This binding causes a conformational change in the mRNA that can affect translation by revealing an expression platform for a downstream gene, or by forming a translation-terminating stem-loop.[2][3][4] The ultimate effects of such translational regulation often take action to manage an abundance of the instigating purine, and might produce proteins that facilitate purine metabolism or purine membrane uptake.[5]
- ^ Mandal, M; Boese B; Barrick JE; Winkler WC; Breaker RR (2003). "Riboswitches Control Fundamental Biochemical Pathways in Bacillus subtilis and Other Bacteria". Cell. 113 (5): 577–586. doi:10.1016/S0092-8674(03)00391-X. PMID 12787499.
- ^ Mandal, M; Breaker RR (2004). "Adenine riboswitches and gene activation by disruption of a transcription terminator". Nat Struct Mol Biol. 11 (1): 29–35. doi:10.1038/nsmb710. PMID 14718920. S2CID 13287755.
- ^ Thirumalai, D; Lin J (2008). "Relative Stability of Helices Determines the Folding Landscape of Adenine Riboswitch Aptamers". Journal of the American Chemical Society. 130 (43): 14080–14081. doi:10.1021/ja8063638. PMID 18828635.
- ^ Batey, RT; Gilbert SD; Montange RK (2004). "Structure of a natural guanine-responsive riboswitch complexed with the metabolite hypoxanthine". Nature. 432 (7015): 411–415. Bibcode:2004Natur.432..411B. doi:10.1038/nature03037. PMID 15549109. S2CID 2462025.
- ^ Sengupta, S; Singh, P (2012). "Phylogenetic Analysis and Comparative Genomics of Purine Riboswitch Distribution in Prokaryotes". Evolutionary Bioinformatics. 8: 589–609. doi:10.4137/EBO.S10048. PMC 3499989. PMID 23170063.