Pydiflumetofen

Pydiflumetofen
Names
	Preferred IUPAC name 3-(Difluoromethyl)-N-methoxy-1-methyl-N-[1-(2,4,6-trichlorophenyl)-2-propanyl]-1H-pyrazole-4-carboxamide
	Other names SYN545974
Identifiers
CAS Number	1228284-64-7 ;
3D model (JSmol)	Interactive image;
Beilstein Reference	20345474
ChEBI	CHEBI:87576 ;
ChemSpider	34501423 ;
ECHA InfoCard	100.252.186
EC Number	817-852-1;
PubChem CID	56933411;
UNII	WHG7I49FAK;
CompTox Dashboard (EPA)	DTXSID60894826 ;
	InChI InChI=1S/C16H16Cl3F2N3O2/c1-8(4-10-12(18)5-9(17)6-13(10)19)24(26-3)16(25)11-7-23(2)22-14(11)15(20)21/h5-8,15H,4H2,1-3H3 Key: DGOAXBPOVUPPEB-UHFFFAOYSA-N ;
	SMILES CC(CC1=C(C=C(C=C1Cl)Cl)Cl)N(C(=O)C2=CN(N=C2C(F)F)C)OC;
Properties
Chemical formula	C16H16Cl3F2N3O2
Molar mass	426.67
Appearance	Off-white solid
Density	g/cm3
Melting point	113°C
Solubility in water	1.5 mg/L (20 °C)
log P	3.8
Hazards
	GHS labelling:
Pictograms
Signal word	Warning
Hazard statements	H351, H361f, H410
Precautionary statements	P203, P273, P280, P318, P391, P405, P501
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Pydiflumetofen is a broad spectrum fungicide used in agriculture to protect crops from fungal diseases. It was first marketed by Syngenta in 2016 using their brand name Miravis. The compound is an amide which combines a pyrazole acid with a substituted phenethylamine to give an inhibitor of succinate dehydrogenase,^[3] an enzyme that inhibits cellular respiration in almost all living organisms.^[4]

^ Pesticide Properties Database. "Pydiflumetofen". University of Hertfordshire.
^ "GHS Classification". pubchem.ncbi.nlm.nih.gov. 2023-07-22. Retrieved 2023-07-27.
^ Irie, Makoto (2017). "Pydiflumetofen" (PDF). FAO. Retrieved 2023-07-27.
^ Bénit, Paule; Kahn, Agathe; Chretien, Dominique; et al. (2019). "Evolutionarily conserved susceptibility of the mitochondrial respiratory chain to SDHI pesticides and its consequence on the impact of SDHIs on human cultured cells". PLOS ONE. 14 (11): e0224132. Bibcode:2019PLoSO..1424132B. doi:10.1371/journal.pone.0224132. PMC 6837341. PMID 31697708.

[PPDB-1] Pesticide Properties Database. "Pydiflumetofen". University of Hertfordshire.

[2] "GHS Classification". pubchem.ncbi.nlm.nih.gov. 2023-07-22. Retrieved 2023-07-27.

[3] Irie, Makoto (2017). "Pydiflumetofen" (PDF). FAO. Retrieved 2023-07-27.

[4] Bénit, Paule; Kahn, Agathe; Chretien, Dominique; et al. (2019). "Evolutionarily conserved susceptibility of the mitochondrial respiratory chain to SDHI pesticides and its consequence on the impact of SDHIs on human cultured cells". PLOS ONE. 14 (11): e0224132. Bibcode:2019PLoSO..1424132B. doi:10.1371/journal.pone.0224132. PMC 6837341. PMID 31697708.

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