Pyruvate dehydrogenase lipoamide kinase isozyme 1

PDK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Q8F, 2Q8G, 2Q8H
Identifiers
Aliases	PDK1, entrez:5163, pyruvate dehydrogenase kinase 1
External IDs	OMIM: 602524; MGI: 1926119; HomoloGene: 134437; GeneCards: PDK1; OMA:PDK1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q31.1 Start 172,555,373 bp[1] End 172,608,669 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C3 Start 71,703,568 bp[2] End 71,734,202 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte skin of hip right ventricle skin of thigh cartilage tissue epithelium of colon jejunal mucosa tonsil endothelial cell mucosa of sigmoid colon Top expressed in iris otic placode saccule atrium atrioventricular junction atrioventricular valve ciliary body Paneth cell Ileal epithelium otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity protein binding ATP binding pyruvate dehydrogenase (acetyl-transferring) kinase activity Cellular component mitochondrial pyruvate dehydrogenase complex mitochondrial matrix nucleus nucleolus mitochondrion Biological process intrinsic apoptotic signaling pathway in response to oxidative stress phosphorylation hypoxia-inducible factor-1alpha signaling pathway regulation of acetyl-CoA biosynthetic process from pyruvate regulation of glucose metabolic process glucose metabolic process cell population proliferation protein phosphorylation carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5163 228026 Ensembl ENSG00000152256 ENSMUSG00000006494 UniProt Q15118 Q8BFP9 RefSeq (mRNA) NM_001278549 NM_002610 NM_172665 NM_001360002 RefSeq (protein) NP_001265478 NP_002601 NP_766253 NP_001346931 Location (UCSC) Chr 2: 172.56 – 172.61 Mb Chr 2: 71.7 – 71.73 Mb PubMed search [3] [4]
Wikidata
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Pyruvate dehydrogenase lipoamide kinase isozyme 1, mitochondrial is an enzyme that in humans is encoded by the PDK1 gene.^[5][6] It codes for an isozyme of pyruvate dehydrogenase kinase (PDK).

Pyruvate dehydrogenase (PDH) is a part of a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation.^[6]