Pyruvate dehydrogenase phosphatase

PDP1
Identifiers
Aliases	PDP1, PDH, PDP, PDPC, PPM2C, PPM2A, pyruvate dehyrogenase phosphatase catalytic subunit 1, pyruvate dehydrogenase phosphatase catalytic subunit 1
External IDs	OMIM: 605993; MGI: 2685870; HomoloGene: 31928; GeneCards: PDP1; OMA:PDP1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	93,926,068 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	11,966,452 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; buccal mucosa cell; ; biceps brachii; ; parietal lobe; ; postcentral gyrus; ; Brodmann area 23; ; right ventricle; ; superior frontal gyrus; ; Skeletal muscle tissue of biceps brachii; ; primary visual cortex;
	Top expressed in
	lateral geniculate nucleus; ; medial dorsal nucleus; ; medial geniculate nucleus; ; olfactory tubercle; ; primary motor cortex; ; prefrontal cortex; ; piriform cortex; ; seminal vesicula; ; cingulate gyrus; ; lateral septal nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein serine/threonine phosphatase activity; protein binding; catalytic activity; phosphoprotein phosphatase activity; hydrolase activity; cation binding; metal ion binding; [pyruvate dehydrogenase (lipoamide) phosphatase activity];
Cellular component	mitochondrial matrix; mitochondrion;
Biological process	protein dephosphorylation; regulation of acetyl-CoA biosynthetic process from pyruvate; peptidyl-threonine dephosphorylation; positive regulation of pyruvate dehydrogenase activity;
	Sources:Amigo / QuickGO
Orthologs
	54704
	381511
	ENSG00000164951
	ENSMUSG00000049225
	Q9P0J1
	Q3UV70
	NM_001161778; NM_001161779; NM_001161780; NM_001161781; NM_018444
	NM_001033453; NM_001098230; NM_001098231; NM_001290387; NM_001290391
	NP_001155251; NP_001155252; NP_001155253; NP_060914
	NP_001028625; NP_001091700; NP_001091701; NP_001277316; NP_001277320
	Wikidata
View/Edit Human	View/Edit Mouse

Pyruvate dehydrogenase phosphatase catalytic subunit 1 (PDPC 1), also known as protein phosphatase 2C, is an enzyme that in humans is encoded by the PDP1 gene.^[5]^[6] PDPC 1 is an enzyme which serves to reverse the effects of pyruvate dehydrogenase kinase upon pyruvate dehydrogenase, activating pyruvate dehydrogenase.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164951 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049225 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: pyruvate dehydrogenase phosphatase catalytic subunit 1".
^ Lawson JE, Niu XD, Browning KS, Trong HL, Yan J, Reed LJ (Sep 1993). "Molecular cloning and expression of the catalytic subunit of bovine pyruvate dehydrogenase phosphatase and sequence similarity with protein phosphatase 2C". Biochemistry. 32 (35): 8987–93. doi:10.1021/bi00086a002. PMID 8396421.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164951 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049225 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: pyruvate dehydrogenase phosphatase catalytic subunit 1".

[pmid8396421-6] Lawson JE, Niu XD, Browning KS, Trong HL, Yan J, Reed LJ (Sep 1993). "Molecular cloning and expression of the catalytic subunit of bovine pyruvate dehydrogenase phosphatase and sequence similarity with protein phosphatase 2C". Biochemistry. 32 (35): 8987–93. doi:10.1021/bi00086a002. PMID 8396421.

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