Pyxis is a constellation in the Southern Hemisphere.
Pyxis may also refer to:
- Pyxis (vessel), a piece of ancient Greek pottery
- Pyxis (turtle), a turtle genus
- Pyxis, a type of capsular fruit where the upper part falls off
- Pyxis, a Japanese idol duo consists of Miku Itō and Moe Toyota
- Pyxis Corporation, a manufacturer of medical technologies and automated dispensing cabinet (ADC) for medications
- Sony Pyxis, an early GPS navigation device launched in 1991