Quinapril

Quinapril
Clinical data
Trade namesAccupril, others
Other namesQuinapril hydrochloride (USAN US)
AHFS/Drugs.comMonograph
MedlinePlusa692026
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding97%
Elimination half-life2 hours
Identifiers
  • (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC25H30N2O5
Molar mass438.524 g·mol−1
3D model (JSmol)
Melting point120 to 130 °C (248 to 266 °F)
  • O=C(OCC)[C@@H](N[C@H](C(=O)N2[C@H](C(=O)O)Cc1c(cccc1)C2)C)CCc3ccccc3
  • InChI=1S/C25H30N2O5/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30)/t17-,21-,22-/m0/s1 checkY
  • Key:JSDRRTOADPPCHY-HSQYWUDLSA-N checkY
  (verify)

Quinapril, sold under the brand name Accupril[2] by the Pfizer corporation. It a medication used to treat high blood pressure (hypertension), heart failure, and diabetic kidney disease.[1][3] It is a first line treatment for high blood pressure.[3] It is taken by mouth.[1][3]

Common side effects include headaches, dizziness, feeling tired, and cough.[3] Serious side effects may include liver problems, low blood pressure, angioedema, kidney problems, and high blood potassium.[3] Use in pregnancy and breastfeeding is not recommended.[4] It is among a class of drugs called ACE inhibitors and works by decreasing renin-angiotensin-aldosterone system activity.[3]

Quinapril was patented in 1980 and came into medical use in 1989.[5] It is available as a generic medication.[6] In 2020, it was the 253rd most commonly prescribed medication in the United States, with more than 1 million prescriptions.[7][8]

  1. ^ a b c "Accupril- quinapril hydrochloride tablet, film coated Accupril- quinapril tablet, film coated". DailyMed. 26 August 2021. Retrieved 25 March 2022.
  2. ^ "ACCUPRIL® Indications and Usage (quinapril HCl) | Pfizer Medical Information - US". www.pfizermedicalinformation.com. Retrieved 25 October 2023.
  3. ^ a b c d e f "Quinapril Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
  4. ^ "Quinapril Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
  5. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 468. ISBN 9783527607495.
  6. ^ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 172. ISBN 9780857113382.
  7. ^ "The Top 300 of 2020". ClinCalc. Retrieved 7 October 2022.
  8. ^ "Quinapril - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.