| Quinolone | |
|---|---|
| Drug class | |
 The second generation fluoroquinolone, ciprofloxacin. The two ringed nitrogen containing system with a ketone is called a quinolone. | |
| Class identifiers | |
| Use | Bacterial infection |
| ATC code | J01M |
| Clinical data | |
| Drugs.com | Drug Classes |
| External links | |
| MeSH | D015363 |
| Legal status | |
| In Wikidata | |
Quinolone antibiotics constitute a large group of broad-spectrum bacteriocidals that share a bicyclic core structure related to the substance 4-quinolone.[1] They are used in human and veterinary medicine to treat bacterial infections, as well as in animal husbandry, specifically poultry production.[2]
Nearly all quinolone antibiotics in use are fluoroquinolones, which contain a fluorine atom in their chemical structure and are effective against both Gram-negative and Gram-positive bacteria. One example is ciprofloxacin, one of the most widely used antibiotics worldwide.[3][4]
- ^ Andriole VT (1989). The Quinolones. Academic Press.
- ^ Johnson JR, Murray AC, Gajewski A, Sullivan M, Snippes P, Kuskowski MA, Smith KE (July 2003). "Isolation and molecular characterization of nalidixic acid-resistant extraintestinal pathogenic Escherichia coli from retail chicken products". Antimicrobial Agents and Chemotherapy. 47 (7): 2161–2168. doi:10.1128/AAC.47.7.2161-2168.2003. PMC 161843. PMID 12821463.
- ^ Andersson MI, MacGowan AP (May 2003). "Development of the quinolones". The Journal of Antimicrobial Chemotherapy. 51 (Suppl S1): 1–11. doi:10.1093/jac/dkg212. PMID 12702698.
- ^ Heeb S, Fletcher MP, Chhabra SR, Diggle SP, Williams P, Cámara M (March 2011). "Quinolones: from antibiotics to autoinducers". FEMS Microbiology Reviews. 35 (2): 247–274. doi:10.1111/j.1574-6976.2010.00247.x. PMC 3053476. PMID 20738404.