RAC1

RAC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E96, 1FOE, 1G4U, 1HE1, 1HH4, 1I4D, 1I4L, 1I4T, 1MH1, 1RYF, 1RYH, 2FJU, 2H7V, 2NZ8, 2P2L, 2RMK, 2VRW, 2WKP, 2WKQ, 2WKR, 2YIN, 3B13, 3BJI, 3RYT, 3SBD, 3SBE, 3SU8, 3SUA, 3TH5, 4GZL, 4GZM, 4YON, 5FI0
Identifiers
Aliases	RAC1, MIG5, Rac-1, TC-25, p21-Rac1, ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1), Rac family small GTPase 1, MRD48
External IDs	OMIM: 602048; MGI: 97845; HomoloGene: 69035; GeneCards: RAC1; OMA:RAC1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p22.1 Start 6,374,527 bp[1] End 6,403,967 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G2|5 82.22 cM Start 143,489,389 bp[2] End 143,513,791 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in visceral pleura middle temporal gyrus postcentral gyrus palpebral conjunctiva gingival epithelium parietal pleura Brodmann area 23 entorhinal cortex Brodmann area 46 Region I of hippocampus proper Top expressed in entorhinal cortex left lung perirhinal cortex tail of embryo CA3 field triceps brachii muscle lactiferous gland choroid plexus of fourth ventricle left lung lobe molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone deacetylase binding Rho GDP-dissociation inhibitor binding GTP-dependent protein binding GTPase activity enzyme binding protein binding thioesterase binding protein kinase binding nucleotide binding GTP binding protein serine/threonine kinase activity protein-containing complex binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity ATPase binding Cellular component cytoplasm cytosol membrane focal adhesion melanosome ruffle membrane trans-Golgi network nucleus cell projection extrinsic component of plasma membrane extracellular exosome lamellipodium early endosome membrane plasma membrane actin filament cytoplasmic ribonucleoprotein granule endoplasmic reticulum membrane Golgi membrane phagocytic cup cytoplasmic vesicle extracellular matrix secretory granule membrane dendritic spine recycling endosome membrane postsynapse glutamatergic synapse ficolin-1-rich granule membrane Biological process positive regulation of Rho protein signal transduction regulation of respiratory burst non-canonical Wnt signaling pathway positive regulation of protein phosphorylation positive regulation of actin filament polymerization regulation of neuron maturation negative regulation of receptor-mediated endocytosis platelet activation Fc-epsilon receptor signaling pathway cellular response to mechanical stimulus phagocytosis, engulfment vascular endothelial growth factor receptor signaling pathway substrate adhesion-dependent cell spreading cell population proliferation ruffle assembly lamellipodium assembly dopaminergic neuron differentiation cell-cell junction organization Fc-gamma receptor signaling pathway involved in phagocytosis ruffle organization actin filament organization cell motility anatomical structure morphogenesis bone resorption response to wounding protein localization to plasma membrane inflammatory response regulation of small GTPase mediated signal transduction positive regulation of cell-substrate adhesion G protein-coupled receptor signaling pathway neuron projection morphogenesis epithelial cell morphogenesis dendrite morphogenesis regulation of hydrogen peroxide metabolic process engulfment of apoptotic cell dendrite development auditory receptor cell morphogenesis hyperosmotic response cerebral cortex GABAergic interneuron development chemotaxis positive regulation of DNA replication actin filament polymerization cell adhesion negative regulation of interleukin-23 production homeostasis of number of cells within a tissue cell-matrix adhesion localization within membrane actin cytoskeleton organization regulation of cell size anatomical structure arrangement intracellular signal transduction regulation of cell migration endocytosis ephrin receptor signaling pathway T cell costimulation blood coagulation mitigation of host defenses by virus synaptic transmission, GABAergic mast cell chemotaxis positive regulation of phosphatidylinositol 3-kinase activity positive regulation of substrate adhesion-dependent cell spreading embryonic olfactory bulb interneuron precursor migration cytoskeleton organization cochlea morphogenesis positive regulation of neutrophil chemotaxis positive regulation of apoptotic process regulation of cell morphogenesis positive regulation of focal adhesion assembly regulation of fibroblast migration positive regulation of lamellipodium assembly cerebral cortex radially oriented cell migration cell migration semaphorin-plexin signaling pathway positive regulation of stress fiber assembly axon guidance small GTPase mediated signal transduction positive regulation of GTPase activity Wnt signaling pathway, planar cell polarity pathway midbrain dopaminergic neuron differentiation neuron migration protein phosphorylation Rho protein signal transduction regulation of lamellipodium assembly Rac protein signal transduction cell projection assembly positive regulation of microtubule polymerization neutrophil degranulation regulation of nitric oxide biosynthetic process phosphatidylinositol phosphate biosynthetic process hepatocyte growth factor receptor signaling pathway regulation of stress fiber assembly positive regulation of protein kinase B signaling motor neuron axon guidance regulation of neutrophil migration positive regulation of insulin secretion involved in cellular response to glucose stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5879 19353 Ensembl ENSG00000136238 ENSMUSG00000001847 UniProt P63000 P63001 RefSeq (mRNA) NM_198829 NM_006908 NM_018890 NM_009007 NM_001347530 RefSeq (protein) NP_008839 NP_061485 NP_001334459 NP_033033 Location (UCSC) Chr 7: 6.37 – 6.4 Mb Chr 5: 143.49 – 143.51 Mb PubMed search [3] [4]
Wikidata
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Ras-related C3 botulinum toxin substrate 1, is a protein that in humans is encoded by the RAC1 gene.^[5][6] This gene can produce a variety of alternatively spliced versions of the Rac1 protein, which appear to carry out different functions.^[7]