RAG2

RAG2
Identifiers
Aliases	RAG2, RAG-2, recombination activating gene 2, recombination activating 2
External IDs	OMIM: 179616; MGI: 97849; HomoloGene: 7507; GeneCards: RAG2; OMA:RAG2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p12 Start 36,575,574 bp[1] End 36,598,279 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 E2|2 53.87 cM Start 101,455,063 bp[2] End 101,462,874 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus bone marrow left lobe of thyroid gland right lobe of thyroid gland bone marrow cells corpus callosum granulocyte mucosa of transverse colon tonsil muscle tissue Top expressed in thymus granulocyte bone marrow heart cochlea exocrine gland hepatobiliary system liver embryo embryonic structure More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding ubiquitin protein ligase activity zinc ion binding chromatin binding phosphatidylinositol-3,5-bisphosphate binding metal ion binding phosphatidylinositol-3,4-bisphosphate binding methylated histone binding phosphatidylinositol binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding sequence-specific DNA binding Cellular component nucleoplasm nucleus DNA recombinase complex Biological process DNA recombination B cell homeostatic proliferation T cell differentiation in thymus positive regulation of organ growth T cell differentiation B cell lineage commitment protein ubiquitination V(D)J recombination pre-B cell allelic exclusion B cell differentiation T cell lineage commitment defense response to bacterium chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5897 19374 Ensembl ENSG00000175097 ENSMUSG00000032864 UniProt P55895 P21784 RefSeq (mRNA) NM_000536 NM_001243785 NM_001243786 NM_009020 RefSeq (protein) NP_000527 NP_001230714 NP_001230715 NP_033046 Location (UCSC) Chr 11: 36.58 – 36.6 Mb Chr 2: 101.46 – 101.46 Mb PubMed search [3] [4]
Wikidata
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Recombination activating gene 2 protein (also known as RAG-2) is a lymphocyte-specific protein encoded by the RAG2 gene on human chromosome 11. Together with the RAG1 protein, RAG2 forms a V(D)J recombinase, a protein complex required for the process of V(D)J recombination during which the variable regions of immunoglobulin and T cell receptor genes are assembled in developing B and T lymphocytes. Therefore, RAG2 is essential for the generation of mature B and T lymphocytes.