RANGAP1

RANGAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z5S, 2GRN, 2GRO, 2GRP, 2GRQ, 2GRR, 2IY0, 3UIN, 3UIO, 3UIP, 5D2M, 2IO2, 2IO3
Identifiers
Aliases	RANGAP1, Fug1, RANGAP, SD, Ran GTPase activating protein 1
External IDs	OMIM: 602362; MGI: 103071; HomoloGene: 55700; GeneCards: RANGAP1; OMA:RANGAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	41,286,187 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	81,629,731 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; Brodmann area 10; ; right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; skin of abdomen; ; Brodmann area 9; ; skin of leg; ; middle frontal gyrus;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; superior surface of tongue; ; spermatid; ; yolk sac; ; visual cortex; ; superior frontal gyrus; ; seminiferous tubule; ; gallbladder; ; primary visual cortex; ; epiblast;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; cadherin binding; RNA binding; GTPase activator activity; ubiquitin protein ligase binding;
Cellular component	intracellular membrane-bounded organelle; cytoplasmic periphery of the nuclear pore complex; nuclear pore; chromosome; dendrite; nuclear pore cytoplasmic filaments; mitotic spindle; chromosome, centromeric region; cytoskeleton; nucleus; kinetochore; axon cytoplasm; cytoplasm; cytosol; aggresome; perinuclear region of cytoplasm; nuclear envelope; nucleoplasm; spindle; nuclear membrane;
Biological process	cellular response to vasopressin; protein sumoylation; cellular response to peptide hormone stimulus; negative regulation of protein export from nucleus; response to axon injury; signal transduction; sister chromatid cohesion; activation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	5905
	19387
	ENSG00000100401
	ENSMUSG00000022391
	P46060
	P46061
	NM_001278651; NM_002883; NM_001317930
	NM_001146174; NM_011241; NM_001358622
	NP_001265580; NP_001304859; NP_002874
	NP_001139646; NP_035371; NP_001345551
	Wikidata
View/Edit Human	View/Edit Mouse

Ran GTPase-activating protein 1 is an enzyme that in humans is encoded by the RANGAP1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100401 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022391 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bischoff FR, Krebber H, Kempf T, Hermes I, Ponstingl H (Apr 1995). "Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport". Proc Natl Acad Sci U S A. 92 (5): 1749–53. Bibcode:1995PNAS...92.1749B. doi:10.1073/pnas.92.5.1749. PMC 42597. PMID 7878053.
^ "Entrez Gene: RANGAP1 Ran GTPase activating protein 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100401 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022391 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7878053-5] Bischoff FR, Krebber H, Kempf T, Hermes I, Ponstingl H (Apr 1995). "Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport". Proc Natl Acad Sci U S A. 92 (5): 1749–53. Bibcode:1995PNAS...92.1749B. doi:10.1073/pnas.92.5.1749. PMC 42597. PMID 7878053.

[entrez-6] "Entrez Gene: RANGAP1 Ran GTPase activating protein 1".

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