RBBP4

RBBP4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XU7, 3GFC, 4PBY, 4PBZ, 4PC0, 4R7A, 5FXY
Identifiers
Aliases	RBBP4, NURF55, RBAP48, lin-53, retinoblastoma binding protein 4, RB binding protein 4, chromatin remodeling factor
External IDs	OMIM: 602923; MGI: 1194912; HomoloGene: 21153; GeneCards: RBBP4; OMA:RBBP4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	32,686,211 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	129,229,163 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; bone marrow cells; ; right testis; ; left testis; ; monocyte; ; epithelium of colon; ; appendix; ; islet of Langerhans; ; stromal cell of endometrium;
	Top expressed in
	Paneth cell; ; medial ganglionic eminence; ; condyle; ; vestibular membrane of cochlear duct; ; fossa; ; vas deferens; ; primitive streak; ; renal corpuscle; ; abdominal wall; ; fetal liver hematopoietic progenitor cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; ATP-dependent activity, acting on DNA; histone binding; histone deacetylase binding; protein binding; nucleosomal DNA binding; histone deacetylase activity;
Cellular component	NuRD complex; ESC/E(Z) complex; CAF-1 complex; Sin3 complex; nucleoplasm; NURF complex; nucleus; cytosol; protein-containing complex;
Biological process	chromatin remodeling; regulation of transcription, DNA-templated; CENP-A containing chromatin assembly; transcription, DNA-templated; regulation of cell cycle; DNA replication-dependent chromatin assembly; DNA replication; negative regulation of gene expression, epigenetic; cell cycle; negative regulation of cell population proliferation; regulation of signal transduction by p53 class mediator; histone deacetylation; response to growth hormone; negative regulation of G0 to G1 transition; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	5928
	19646
	ENSG00000162521
	ENSMUSG00000057236
	Q09028
	Q60972
	NM_005610; NM_001135255; NM_001135256
	NM_009030
	NP_001128727; NP_001128728; NP_005601
	NP_033056
	Wikidata
View/Edit Human	View/Edit Mouse

Histone-binding protein RBBP4 (also known as RbAp48, or NURF55) is a protein that in humans is encoded by the RBBP4 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162521 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057236 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Qian YW, Wang YC, Hollingsworth RE Jr, et al. (September 1993). "A retinoblastoma-binding protein related to a negative regulator of Ras in yeast". Nature. 364 (6438): 648–52. Bibcode:1993Natur.364..648Q. doi:10.1038/364648a0. PMID 8350924. S2CID 4303062.
^ Barak O, Lazzaro MA, Lane WS, et al. (November 2003). "Isolation of human NURF: a regulator of Engrailed gene expression". EMBO J. 22 (22): 6089–100. doi:10.1093/emboj/cdg582. PMC 275440. PMID 14609955.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162521 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057236 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8350924-5] Qian YW, Wang YC, Hollingsworth RE Jr, et al. (September 1993). "A retinoblastoma-binding protein related to a negative regulator of Ras in yeast". Nature. 364 (6438): 648–52. Bibcode:1993Natur.364..648Q. doi:10.1038/364648a0. PMID 8350924. S2CID 4303062.

[pmid14609955-6] Barak O, Lazzaro MA, Lane WS, et al. (November 2003). "Isolation of human NURF: a regulator of Engrailed gene expression". EMBO J. 22 (22): 6089–100. doi:10.1093/emboj/cdg582. PMC 275440. PMID 14609955.

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