RBCG30

rBCG30 (recombinant Bacillus Calmette-Guérin 30) is a prospective Bacillus Calmette-Guérin vaccine against tuberculosis. It is a live vaccine, consisting of BCG, which has been evaluated as a tuberculosis vaccination. It is genetically modified to produce abundant amounts of mycolyl transferase, a 30kDa antigen (Antigen 85B)[1] that has been shown to produce a strong immune response in animals[2][3][4][5] and humans. rBCG30 had been in human clinical trials, [6] but no clinical development has been reported since 2007.[7]

  1. ^ Horwitz MA (May 2005). "Recombinant BCG expressing Mycobacterium tuberculosis major extracellular proteins". Microbes and Infection. 7 (5–6): 947–54. doi:10.1016/j.micinf.2005.04.002. PMID 15919223.
  2. ^ Horwitz MA, Harth G, Dillon BJ, Maslesa-Galic' S (December 2000). "Recombinant bacillus calmette-guerin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model". Proceedings of the National Academy of Sciences of the United States of America. 97 (25): 13853–13858. Bibcode:2000PNAS...9713853H. doi:10.1073/pnas.250480397. PMC 17665. PMID 11095745.
  3. ^ Horwitz MA, Harth G (April 2003). "A new vaccine against tuberculosis affords greater survival after challenge than the current vaccine in the guinea pig model of pulmonary tuberculosis". Infection and Immunity. 71 (4): 1672–1679. doi:10.1128/iai.71.4.1672-1679.2003. PMC 152073. PMID 12654780.
  4. ^ Horwitz MA, Harth G, Dillon BJ, Maslesa-Galić S (January 2006). "Extraordinarily few organisms of a live recombinant BCG vaccine against tuberculosis induce maximal cell-mediated and protective immunity". Vaccine. 24 (4): 443–451. doi:10.1016/j.vaccine.2005.08.001. PMID 16125825. S2CID 8581702.
  5. ^ Horwitz MA, Harth G, Dillon BJ, Maslesa-Galić S (March 2006). "A novel live recombinant mycobacterial vaccine against bovine tuberculosis more potent than BCG". Vaccine. 24 (10): 1593–1600. doi:10.1016/j.vaccine.2005.10.002. PMID 16257099. S2CID 11798572.
  6. ^ Cite error: The named reference Hoft_2008 was invoked but never defined (see the help page).
  7. ^ "Recombinant BCG vaccine - Aeras Global TB Vaccine Foundation/ UCLA". AdisInsight. Springer Nature Switzerland AG.