Meiotic recombination protein REC8 homolog is a protein that in humans is encoded by the REC8 gene.[5][6][7][8]
Rec8 is a meiosis-specific component of the cohesin complex that binds sister chromatids in preparation for the two divisions of meiosis. Rec8 is sequentially removed from sister chromatids. It is removed from the arms of chromosomes in the first division - separating homologous chromosomes from each other. However, Rec8 is maintained at centromeres so that sister chromatids are kept joined until anaphase of meiosis II, at which point removal of remaining cohesin leads to the separation of sister chromatids.
- ^ a b c GRCh38: Ensembl release 89: ENSG00000100918 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002324 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Parisi S, McKay MJ, Molnar M, Thompson MA, van der Spek PJ, van Drunen-Schoenmaker E, Kanaar R, Lehmann E, Hoeijmakers JH, Kohli J (May 1999). "Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans". Molecular and Cellular Biology. 19 (5): 3515–28. doi:10.1128/MCB.19.5.3515. PMC 84144. PMID 10207075.
- ^ Xu H, Beasley MD, Warren WD, van der Horst GT, McKay MJ (Jun 2005). "Absence of mouse REC8 cohesin promotes synapsis of sister chromatids in meiosis". Developmental Cell. 8 (6): 949–61. doi:10.1016/j.devcel.2005.03.018. PMID 15935783.
- ^ Lee J, Iwai T, Yokota T, Yamashita M (Jul 2003). "Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis". Journal of Cell Science. 116 (Pt 13): 2781–90. doi:10.1242/jcs.00495. PMID 12759374. S2CID 11040339.
- ^ "Entrez Gene: REC8L1 REC8-like 1 (yeast)".