RECQL5

RECQL5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BK0, 5LB8, 5LB5, 5LBA, 5LB3
Identifiers
Aliases	RECQL5, RECQ5, RecQ like helicase 5
External IDs	OMIM: 603781; MGI: 2156841; HomoloGene: 31232; GeneCards: RECQL5; OMA:RECQL5 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	75,667,189 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	115,824,303 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; right uterine tube; ; left lobe of thyroid gland; ; left testis; ; anterior pituitary; ; right testis; ; sural nerve; ; skin of abdomen; ; body of stomach; ; skin of leg;
	Top expressed in
	granulocyte; ; zygote; ; spermatid; ; neural layer of retina; ; secondary oocyte; ; lip; ; tail of embryo; ; corneal stroma; ; ventricular zone; ; plantaris muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II complex binding; nucleotide binding; helicase activity; DNA helicase activity; nucleic acid binding; hydrolase activity; ATP binding; DNA binding; 3'-5' DNA helicase activity; four-way junction helicase activity; protein binding; identical protein binding;
Cellular component	RNA polymerase II, holoenzyme; nucleoplasm; nucleus; chromosome; cytoplasm; cytosol;
Biological process	DNA recombination; DNA metabolic process; negative regulation of transcription elongation from RNA polymerase II promoter; cellular response to DNA damage stimulus; cell division; chromosome separation; DNA replication; cell cycle; DNA repair; DNA duplex unwinding; double-strand break repair via homologous recombination; cellular response to camptothecin; replication-born double-strand break repair via sister chromatid exchange; negative regulation of double-strand break repair via homologous recombination; mitotic cell cycle; mitotic sister chromatid segregation; response to X-ray; negative regulation of mitotic cell cycle; DNA unwinding involved in DNA replication; metabolism;
	Sources:Amigo / QuickGO
Orthologs
	9400
	170472
	ENSG00000108469
	ENSMUSG00000020752
	O94762
	Q8VID5
	NM_001003715; NM_001003716; NM_004259
	NM_130454
	NP_001003715; NP_001003716; NP_004250
	NP_569721
	Wikidata
View/Edit Human	View/Edit Mouse

ATP-dependent DNA helicase Q5 is an enzyme that in humans is encoded by the RECQL5 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108469 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020752 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kitao S, Ohsugi I, Ichikawa K, Goto M, Furuichi Y, Shimamoto A (Dec 1998). "Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes". Genomics. 54 (3): 443–52. doi:10.1006/geno.1998.5595. PMID 9878247.
^ "Entrez Gene: RECQL5 RecQ protein-like 5".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108469 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020752 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9878247-5] Kitao S, Ohsugi I, Ichikawa K, Goto M, Furuichi Y, Shimamoto A (Dec 1998). "Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes". Genomics. 54 (3): 443–52. doi:10.1006/geno.1998.5595. PMID 9878247.

[entrez-6] "Entrez Gene: RECQL5 RecQ protein-like 5".

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