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REX2 is a proprietary type of audio sample loop file format developed by Reason Studios, a Swedish music software company.
It is one of the most popular and widely supported loop file formats for sequencer and digital audio workstation software. It is supported by PreSonus Studio One, Reason Studios Reason, Steinberg Cubase, Steinberg Nuendo, Cockos REAPER, Apple Logic, Avid Pro Tools, Ableton Live, Cakewalk Project5, Cakewalk Sonar, Image-Line FL Studio, MOTU Digital Performer, MOTU Mach 5 (software sampler), and Synapse Audio Orion Platinum, among others.
REX files are named after the three-letter filename suffix for "ReCycle EXport," as these are files generated by Reason Studios's ReCycle looping utility. The filename extensions for the file format are .rex and .rx2.