RHEB

RHEB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XTQ, 1XTR, 1XTS, 3SEA, 3T5G
Identifiers
Aliases	RHEB, RHEB2, Ras homolog enriched in brain, Ras homolog, mTORC1 binding
External IDs	OMIM: 601293; MGI: 97912; HomoloGene: 123916; GeneCards: RHEB; OMA:RHEB - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q36.1 Start 151,466,012 bp[1] End 151,520,120 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 A3 Start 25,007,821 bp[2] End 25,047,622 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence smooth muscle tissue Brodmann area 9 gastric mucosa cingulate gyrus anterior cingulate cortex muscle layer of sigmoid colon left adrenal cortex right frontal lobe Top expressed in otic vesicle Epithelium of choroid plexus saccule Region I of hippocampus proper otic placode facial motor nucleus condyle vestibular sensory epithelium nucleus of stria terminalis medial ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding metal ion binding protein binding protein kinase binding magnesium ion binding GTPase activity GTP binding GDP binding Cellular component cytoplasm cytosol Golgi apparatus endoplasmic reticulum membrane membrane Golgi membrane lysosomal membrane endoplasmic reticulum spliceosomal complex extracellular exosome endomembrane system postsynaptic density plasma membrane Biological process positive regulation of oligodendrocyte differentiation regulation of TOR signaling regulation of type B pancreatic cell development positive regulation of TOR signaling signal transduction regulation of macroautophagy negative regulation of cold-induced thermogenesis small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6009 19744 Ensembl ENSG00000106615 ENSMUSG00000028945 UniProt Q15382 Q921J2 RefSeq (mRNA) NM_005614 NM_053075 RefSeq (protein) NP_005605 NP_444305 Location (UCSC) Chr 7: 151.47 – 151.52 Mb Chr 5: 25.01 – 25.05 Mb PubMed search [3] [4]
Wikidata
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RHEB also known as Ras homolog enriched in brain (RHEB) is a GTP-binding protein that is ubiquitously expressed in humans and other mammals. The protein is largely involved in the mTOR pathway and the regulation of the cell cycle.^[5]

RHEB is a recently discovered member of the Ras superfamily. Being a relative of Ras, the overexpression of RHEB can be seen in multiple human carcinomas.^[6] For this reason, ways to inhibit RHEB to control the mTOR pathway are studied as possible treatments for uncontrollable tumor cell growth in several diseases, especially in tuberous sclerosis.^[7]