RICS (gene)

ARHGAP32
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3IUG
Identifiers
Aliases	ARHGAP32, GC-GAP, GRIT, PX-RICS, RICS, p200RhoGAP, p250GAP, Rho GTPase activating protein 32
External IDs	OMIM: 608541; MGI: 2450166; HomoloGene: 8812; GeneCards: ARHGAP32; OMA:ARHGAP32 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	129,279,324 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	32,179,742 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; secondary oocyte; ; postcentral gyrus; ; endothelial cell; ; Brodmann area 23; ; superior frontal gyrus; ; primary visual cortex; ; entorhinal cortex; ; sural nerve; ; palpebral conjunctiva;
	Top expressed in
	primary motor cortex; ; cingulate gyrus; ; lateral geniculate nucleus; ; olfactory tubercle; ; prefrontal cortex; ; lateral septal nucleus; ; anterior amygdaloid area; ; piriform cortex; ; mammillary body; ; ventromedial nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; phosphatidylinositol binding; GTPase activator activity; phosphatidylinositol phosphate binding;
Cellular component	cytoplasm; cytosol; endosome; postsynaptic membrane; cell projection; endoplasmic reticulum membrane; membrane; postsynaptic density; Golgi membrane; plasma membrane; dendritic spine; synapse; cell junction; endoplasmic reticulum; endosome membrane; fibrillar center; nucleoplasm; Golgi apparatus; cell cortex; actin cytoskeleton;
Biological process	positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction; small GTPase mediated signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	9743
	330914
	ENSG00000134909
	ENSMUSG00000041444
	A7KAX9
	Q811P8
	NM_001142685; NM_014715; NM_001378024; NM_001378025
	NM_001195632; NM_177379; NM_001370957; NM_001370958
	NP_001136157; NP_055530; NP_001364953; NP_001364954
	NP_001182561; NP_796353; NP_001357886; NP_001357887
	Wikidata
View/Edit Human	View/Edit Mouse

Rho GTPase-activating protein 32 is a protein that in humans is encoded by the RICS gene.^[5] RICS has two known isoforms, RICS that are expressed primarily at neurite growth cones, and at the post synaptic membranes, and PX-RICS which is more widely expressed in the endoplasmic reticulum, Golgi apparatus and endosomes.^[6] The only known domain of the RICS is the RhoGAP domain, whilst PX-RICS has an additional Phox homology and SH3 domain.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134909 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041444 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: RICS Rho GTPase-activating protein".
^ Okabe T, Nakamura T, Nishimura YN, Kohu K, Ohwada S, Morishita Y, Akiyama T (March 2003). "RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling". J. Biol. Chem. 278 (11): 9920–7. doi:10.1074/jbc.M208872200. PMID 12531901.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134909 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041444 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: RICS Rho GTPase-activating protein".

[Okabe_2003-6] Okabe T, Nakamura T, Nishimura YN, Kohu K, Ohwada S, Morishita Y, Akiyama T (March 2003). "RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling". J. Biol. Chem. 278 (11): 9920–7. doi:10.1074/jbc.M208872200. PMID 12531901.

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