| Zinc finger, C3HC4 type (RING finger) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of the C3HC4 domain.[1] Zinc ions are black spheres, coordinated by cysteines residues (blue). | |||||||||
| Identifiers | |||||||||
| Symbol | zf-C3HC4 | ||||||||
| Pfam | PF00097 | ||||||||
| Pfam clan | CL0229 | ||||||||
| ECOD | 376.1.1 | ||||||||
| InterPro | IPR001841 | ||||||||
| SMART | SM00184 | ||||||||
| PROSITE | PDOC00449 | ||||||||
| SCOP2 | 1chc / SCOPe / SUPFAM | ||||||||
| |||||||||
In molecular biology, a RING (short for Really Interesting New Gene) finger domain is a protein structural domain of zinc finger type which contains a C3HC4 amino acid motif which binds two zinc cations (seven cysteines and one histidine arranged non-consecutively).[2][3][4][5] This protein domain contains 40 to 60 amino acids. Many proteins containing a RING finger play a key role in the ubiquitination pathway. Conversely, proteins with RING finger domains are the largest type of ubiquitin ligases in the human genome.[6]
- ^ Barlow PN, Luisi B, Milner A, Elliott M, Everett R (March 1994). "Structure of the C3HC4 domain by 1H-nuclear magnetic resonance spectroscopy. A new structural class of zinc-finger". J. Mol. Biol. 237 (2): 201–11. doi:10.1006/jmbi.1994.1222. PMID 8126734.
- ^ Borden KL, Freemont PS (1996). "The RING finger domain: a recent example of a sequence-structure family". Curr. Opin. Struct. Biol. 6 (3): 395–401. doi:10.1016/S0959-440X(96)80060-1. PMID 8804826.
- ^ Hanson IM, Poustka A, Trowsdale J (1991). "New genes in the class II region of the human major histocompatibility complex". Genomics. 10 (2): 417–24. doi:10.1016/0888-7543(91)90327-B. PMID 1906426.
- ^ Freemont PS, Hanson IM, Trowsdale J (1991). "A novel cysteine-rich sequence motif". Cell. 64 (3): 483–4. doi:10.1016/0092-8674(91)90229-R. PMID 1991318.
- ^ Lovering R, Hanson IM, Borden KL, Martin S, O'Reilly NJ, Evan GI, Rahman D, Pappin DJ, Trowsdale J, Freemont PS (1993). "Identification and preliminary characterization of a protein motif related to the zinc finger". Proc. Natl. Acad. Sci. U.S.A. 90 (6): 2112–6. Bibcode:1993PNAS...90.2112L. doi:10.1073/pnas.90.6.2112. PMC 46035. PMID 7681583.
- ^ Scalia, Pierluigi; Williams, Stephen J.; Suma, Antonio; Carnevale, Vincenzo (2023-06-21). "The DTX Protein Family: An Emerging Set of E3 Ubiquitin Ligases in Cancer". Cells. 12 (13): 1680. doi:10.3390/cells12131680. ISSN 2073-4409. PMC 10340142. PMID 37443713.