RNA-binding protein EWS

EWSR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CPE
Identifiers
Aliases	EWSR1, EWS, bK984G1.4, EWS-FLI1, Ewing sarcoma breakpoint region 1, EWS RNA binding protein 1
External IDs	OMIM: 133450; MGI: 99960; HomoloGene: 136069; GeneCards: EWSR1; OMA:EWSR1 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	29,300,525 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	5,099,266 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; left testis; ; right testis; ; right hemisphere of cerebellum; ; right lobe of thyroid gland; ; right adrenal cortex; ; left adrenal cortex; ; ganglionic eminence; ; body of uterus; ; left lobe of thyroid gland;
	Top expressed in
	yolk sac; ; neural layer of retina; ; ventricular zone; ; genital tubercle; ; tail of embryo; ; superior frontal gyrus; ; primary visual cortex; ; spermatocyte; ; spermatid; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein binding; calmodulin binding; identical protein binding; nucleic acid binding; RNA binding;
Cellular component	cytoplasm; plasma membrane; nucleolus; membrane; nucleus;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	2130
	14030
	ENSG00000182944
	ENSMUSG00000009079
	Q01844
	Q61545
	NM_001163285; NM_001163286; NM_001163287; NM_005243; NM_013986
	NM_001283061; NM_001283062; NM_001283063; NM_007968
	NP_001156757; NP_001156758; NP_001156759; NP_005234; NP_053733
NP_001269990; NP_001269991; NP_001269992; NP_031994; NP_001349541;
	NP_001349542; NP_001349543; NP_001349544; NP_001349545; NP_001349546; NP_001349547; NP_001349549
	Wikidata
View/Edit Human	View/Edit Mouse

RNA-binding protein EWS is a protein that in humans is encoded by the EWSR1 gene on human chromosome 22, specifically 22q12.2.^[5]^[6] It is one of 3 proteins in the FET protein family.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182944 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000009079 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M, Kovar H, Joubert I, de Jong P, Rouleau G (October 1992). "Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours". Nature. 359 (6391): 162–5. Bibcode:1992Natur.359..162D. doi:10.1038/359162a0. PMID 1522903. S2CID 4331584.
^ "Entrez Gene: EWSR1 Ewing sarcoma breakpoint region 1".
^ Flucke U, van Noesel MM, Siozopoulou V, Creytens D, Tops BB, van Gorp JM, Hiemcke-Jiwa LS (June 2021). "EWSR1-The Most Common Rearranged Gene in Soft Tissue Lesions, Which Also Occurs in Different Bone Lesions: An Updated Review". Diagnostics (Basel, Switzerland). 11 (6): 1093. doi:10.3390/diagnostics11061093. PMC 8232650. PMID 34203801.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182944 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000009079 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1522903-5] Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M, Kovar H, Joubert I, de Jong P, Rouleau G (October 1992). "Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours". Nature. 359 (6391): 162–5. Bibcode:1992Natur.359..162D. doi:10.1038/359162a0. PMID 1522903. S2CID 4331584.

[entrez-6] "Entrez Gene: EWSR1 Ewing sarcoma breakpoint region 1".

[pmid34203801-7] Flucke U, van Noesel MM, Siozopoulou V, Creytens D, Tops BB, van Gorp JM, Hiemcke-Jiwa LS (June 2021). "EWSR1-The Most Common Rearranged Gene in Soft Tissue Lesions, Which Also Occurs in Different Bone Lesions: An Updated Review". Diagnostics (Basel, Switzerland). 11 (6): 1093. doi:10.3390/diagnostics11061093. PMC 8232650. PMID 34203801.

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